女性苗勒氏管发育异常相关基因的研究进展  

Research Progress of Genes Related to Female Müllerian Duct Anomalies

作　　者：刘威兰 黄向华[2] LIU Weilan;HUANG Xianghua(Department of Gynecology,Hebei General Hospital,Shijiazhuang 050057,China;Department of Gynecology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北省人民医院妇科,石家庄050057 [2]河北医科大学第二医院妇科,石家庄050000

出　　处：《医学综述》2022年第14期2768-2774,共7页Medical Recapitulate

摘　　要：苗勒氏管发育异常(MDA)表现为女性生殖道缺失或发育畸形,严重影响女性的身心健康。MDA的临床表现复杂多样,其发病原因及机制尚不完全明确,不利于该病的预防及诊疗。胚胎发育过程需基因等遗传因素的精准调控,若其中某些基因出现突变或表达异常可能影响胚胎器官的正常发育。深入探究与女性生殖道发育相关的基因,并分析其是否存在异常,可从遗传层面推测MDA的致病因素。目前已有学者通过分子遗传学技术进行了若干候选基因的检测,但目前尚未得到明确结论。未来仍需大量并深入的工作以研究MDA的候选基因及其他相关因素,为MDA的病因探索寻找更多方向。Müllerian duct anomalies(MDA)are characterized by the absence or abnormality of female reproductive tract,which are seriously detrimental to women′s physical and mental health.The clinical manifestations of MDA are diverse and complex,while the etiology and pathogenesis are still not completely clear at present,which are not conducive to the prevention and treatment of this disease.Precise regulation of genetic factors such as genes is required for the process of embryonic development,and the normal development of embryonic organs can be affected by mutations or abnormal expression of some genes.The pathogenic factors of MDA can be predicted from the genetic level by further exploring the genes related to female reproductive tract development and analyzing whether there are abnormalities in them.At present,some candidate genes have been detected through molecular genetics technology,but no clear conclusions have been reached.In the future,a large number of in-depth researches are still needed to study the candidate genes and other related factors of MDA,so as to find more directions for exploring the etiology of MDA.

关 键 词：苗勒氏管发育异常 生殖道畸形 遗传因素 候选基因 突变 

分 类 号：R711.1[医药卫生—妇产科学]