细胞因子与非小细胞肺癌手术患者预后关系的研究进展  

Research Progress in Relationship between Cytokines and Prognosis of Patients with Non-small Cell Lung Cancer Surgery

作　　者：陈平[1] 张鹤 赵云龙 CHEN Ping;ZHANG He;ZHAO Yunlong(Department of Thoracic Surgery,the Fourth Medical Center of PLA General Hospital,Beijing 100048,China;Department of Oncology,the Fourth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]解放军总医院第四医学中心胸外科,北京100048 [2]解放军总医院第四医学中心肿瘤内科,北京100048

出　　处：《医学综述》2022年第14期2795-2800,共6页Medical Recapitulate

摘　　要：肺癌新发病例及病死病例数位居恶性肿瘤之首,其中非小细胞肺癌(NSCLC)具有复发率高、侵袭性强的特点,多数患者术后生存率较低,预后相对更差。NSCLC病情进展与炎症反应、免疫功能等有关,众多细胞因子参与其中,如白细胞介素(IL)类细胞因子(IL-6、IL-17、IL-33)、T淋巴细胞可通过相应机制参与NSCLC进展过程,从而影响病情转归。但由于细胞因子种类较多,且不同细胞因子在NSCLC进展过程中的作用机制具有多样性,明确各因子的作用机制及其与NSCLC的关系,有利于改善NSCLC患者病情和预后。The number of new cases and death cases of lung cancer ranks first among malignant tumors,especially that non-small cell lung cancer(NSCLC)has the characteristics of high recurrence rate and strong invasion,most patients of which have low postoperative survival rate and poor prognosis.The progression of NSCLC is related to inflammatory response and immune function,and many cytokines are involved.For example,interleukin(IL)cytokines(IL-6,IL-17,IL-33),T lymphocytes can participate in the progression of NSCLC through corresponding mechanisms,thus affecting the prognosis of NSCLC.However,because there are many kinds of cytokines and the action mechanisms of different cytokines are diverse in the progression of NSCLC,clarifying the action mechanism of each factor and their relationships with NSCLC is helpful to improve the disease condition and prognosis of the NSCLC patients.

关 键 词：非小细胞肺癌 白细胞介素-6 白细胞介素-17 白细胞介素-33 T淋巴细胞 血管内皮生长因子 胰岛素样生长因子-1 

分 类 号：R734.2[医药卫生—肿瘤]