低可发酵的低聚糖、双糖、单糖及多元醇饮食治疗腹泻型肠易激综合征的研究进展  

Research Progress of Low Fermentable Oligosaccharides,Disaccharides,Monosaccharides and Polyols Diet in Treatment of Diarrhea-type Irritable Bowel Syndrome

作　　者：王云[1] 赵崧[2] WANG Yun;ZHAO Song(Nanjing University of Chinese Medicine,Nanjing 210023,China;Department of Gastroenterology,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学,南京210023 [2]南京中医药大学附属医院消化科,南京210029

出　　处：《医学综述》2022年第14期2871-2876,2883,共7页Medical Recapitulate

基　　金：国家自然科学基金(81774243);江苏省研究生科研与实践创新计划项目(SJCX22_0741)。

摘　　要：以反复发作的腹痛、腹部不适、腹泻及情绪异常为主要临床表现的腹泻型肠易激综合征(IBS-D),近年来被认为与饮食因素密切相关,IBS-D患者胃肠道症状与含有某些短链碳水化合物的食物摄入量密切相关,并将这一类饮食统称可发酵的低聚糖、双糖、单糖及多元醇(FODMAP)饮食,高FODMAP饮食诱发胃肠道症状的机制可能涉及增加肠腔渗透压、增加肠腔产气量、改变肠道菌群与增高内脏敏感性等方面,且减少每天FODMAP的摄入量能明显改善IBS-D症状。故低FODMAP饮食有望替代传统建议饮食成为IBS-D患者的建议饮食方式。Irritable bowel syndrome with predominant diarrhea(IBS-D)with recurrent abdominal pain,abdominal discomfort,diarrhea and abnormal mood as its main clinical manifestations,is considered to be closely related to dietary factors in recent years.The gastrointestinal symptoms of IBS-D patients are closely related to food intake containing some short-chain carbohydrates,namely fermentable oligosaccharides,disaccharides,monosaccharides and polyols(FODMAP)diet.The mechanisms of gastrointestinal symptoms induced by high FODMAP diet may involve increasing intestinal osmotic pressure,increasing intestinal gas production,changing intestinal flora and increasing visceral sensitivity,and reducing daily FODMAP intake can significantly improve IBS-D symptoms.Therefore,the low FODMAP diet is expected to replace the traditional diet as the diet for IBS-D patients.

关 键 词：腹泻型肠易激综合征 低FODMAP饮食 治疗机制 

分 类 号：R574[医药卫生—消化系统]