Wnt/β-catenin信号通路在多发性骨髓瘤中的机制研究进展  

The research progress on the mechanism of Wnt/β-catenin signaling pathway involved in multiple myeloma

作　　者：许家威 郭一慧 宋辉 程纬民[2] XU Jiawei;GUO Yihui;SONG Hui;CHENG Weimin(Guangxi University of Chinese Medicine,Nanning 530200,China;Department of Hematology,the First Affiliated Hospital of Guangxi University of Chinese Medicine)

机构地区：[1]广西中医药大学,530200 [2]广西中医药大学第一附属医院血液内科

出　　处：《天津医药》2022年第8期888-891,共4页Tianjin Medical Journal

基　　金：国家自然科学基金地区科学基金项目(81960839);广西研究生教育创新计划项目(YCSW2021224)。

摘　　要：多发性骨髓瘤(MM)是一种以骨髓浆细胞恶性增殖为特征的血液肿瘤,其发生机制与相关的信号通路异常有着密切关系。Wnt/β-catenin信号通路可参与调节细胞的增殖、分化和凋亡等生物学过程,且与细胞癌变相关。在MM中,异常表达的非编码RNAs、转录因子、蛋白酶和分泌蛋白等可激活Wnt/β-catenin信号通路,进而加速MM的发生和发展。因此,Wnt/β-catenin信号通路在MM的发病机制中具有重要地位。整理总结MM中相关非编码RNAs、转录因子、蛋白酶和分泌蛋白等影响Wnt/β-catenin信号通路的研究进展,以期为相关研究提供参考。Multiple myeloma(MM)is a hematological tumor characterized by malignant proliferation of bone marrow plasma cells,and its mechanism of occurrence is closely related to the abnormalities of related signaling pathways.Wnt/β-catenin signaling pathway is involved in the regulation of cell proliferation,differentiation,apoptosis and other biological processes,and it is associated with cell carcinomatosis.In MM,abnormally expressed non-coding RNAs,transcription factors,proteases and secreted proteins can activate the Wnt/β-catenin signaling pathway,thus accelerating the occurrence and development of MM.Therefore,Wnt/β-catenin signaling pathway plays an important role in the pathogenesis of MM.This paper collates and summarizes the research progress of relevant non-coding RNAs,transcription factors,proteases and secretory proteins in MM that affect the Wnt/β-catenin signaling pathway,in order to provide reference for related research.

关 键 词：多发性骨髓瘤 生物标记 肿瘤 WNT信号通路 Β连环素 

分 类 号：R733.3[医药卫生—肿瘤]