Ataxia-telangiectasia mutated plays an important role in cerebellar integrity and functionality  

作　　者：Yulia Mitiagin Ari Barzilai 

机构地区：[1]Department of Neurobiology,the School of Neurobiology,Biophysics,Molecular Biology and Biochemistry,George S.Wise,Faculty of Life Sciences,Tel Aviv University,Tel Aviv,Israel [2]Sagol School of Neurosciences,Tel Aviv University,Tel Aviv,Israel

出　　处：《Neural Regeneration Research》2023年第3期497-502,共6页中国神经再生研究（英文版）

摘　　要：Accumulating evidence indicates that ataxia-telangiectasia mutated kinase is critical for maintaining cellular homeostasis and that it has both nuclear and cytoplasmic functions.However,the functions of ataxia-telangiectasia mutated that when lost lead to cerebellar degeneration are still unknown.In this review,we first describe the role of ataxia-telangiectasia mutated in cerebellar pathology.In addition to its canonical nuclear functions in DNA damage response circuits,ataxia-telangiectasia mutated functions in various cytoplasmic and mitochondrial processes that are critically important for cellular homeostasis.We discuss these functions with a focus on the role of ataxia-telangiectasia mutated in maintaining the homeostatic redox state.Finally,we describe the unique functions of ataxia-telangiectasia mutated in various types of neuronal and glial cells including cerebellar granule neurons,astrocytes,and microglial cells.

关 键 词：ataxia telangiectasia ATM CEREBELLUM DNA damage response double-strand breaks mitochondrial dysfunction oxidative stress single-strand breaks 

分 类 号：R651.3[医药卫生—外科学]