Synaptic alterations as a common phase in neurological and neurodevelopmental diseases: JNK is a key mediator in synaptic changes  

作　　者：Clara Alice Musi Carlo Bonadonna Tiziana Borsello 

机构地区：[1]Department of Pharmacological and Biomolecular Sciences,Universitàdegli Studi di Milano,Milano,Italy [2]Mario Negri Insitute for Pharmacolgical Research-IRCCS,Milano,Italy

出　　处：《Neural Regeneration Research》2023年第3期531-532,共2页中国神经再生研究（英文版）

基　　金：funded by Ricerca Finalizzata 2016 RF-2016-02361941;MIUR,-PON“Ricerca e Innovazione”PerMedNet id project ARS01_01226-PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE Prot.2017MYJ5TH;312 European Commission’s Horizon 2020 research and innovation program,No.847749。

摘　　要：Brain synapses play a key role in neuronal communication:this“conversation”is at the basis of all brain activities and synaptic dysfunction leads to brain disorders.We study the modulators of this crucial synaptic function and we here present the evidence supporting the c-Jun N-terminal kinase(JNK)pathway as a pivotal actor in this scenario.

关 键 词：alterations diseases NEUROLOGICAL 

分 类 号：R741[医药卫生—神经病学与精神病学]