Association between brain N-acetylaspartate levels and sensory and motor dysfunction in patients who have spinal cord injury with spasticity:an observational case-control study  

作　　者：Jia-Yi Liu Ya-Jing Li Xin-Ying Cong Zuliyaer Talifu Xin Zhang Feng Gao Jian-Jun Li 

机构地区：[1]School of Rehabilitation,Capital Medical University,Beijing,China [2]Department of Spinal and Neural Function Reconstruction,China Rehabilitation Research Center,Beijing,China [3]China Rehabilitation Science Institute,Beijing,China [4]Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China [5]Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China [6]Rehabilitation Department,Shanghai Huashan Hospital,Shanghai,China [7]Department of Medical Imaging,China Rehabilitation Research Center,Beijing,China

出　　处：《Neural Regeneration Research》2023年第3期582-586,共5页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82071400,81870979;the Scientific Research Foundation of China Rehabilitation Research Center,No.2020cz-01;the Special Capital Health Research and Development of China,No.2018-1-6011(all to JJL)。

摘　　要：Spinal cord injury is a severe and devastating disease,and spasticity is a common and severe complication that is notoriously refractory to treatment.However,the pathophysiological mechanisms underlying spasticity and its development remain largely unknown.The goal of the present study was to find differences,if any,in metabolites of the left precentral gyrus and basal ganglia of patients who have spinal cord injury with or without spasticity,and to explore the relationship between the brain metabolite concentrations and clinical status.Thirty-six participants were recruited for magnetic resonance spectroscopic examination:23 with spinal cord injury(12 with spasticity and 11 without spasticity)and 13 healthy controls.We acquired localized proton spectra from the precentral gyrus and basal ganglia via 10 mm^(3) voxels.Notably,univariate linear regression analysis demonstrated that the lower that the N-acetylaspartate concentration(a marker for neuronal loss)was in the precentral gyrus of the patients,the lower their ASIA(American Spinal Injury Association)light-touch scores,pinprick scores,and motor scores.Additionally,longer durations of injury were associated with higher N-acetylaspartate levels in the precentral gyrus.Compared with the healthy participants and patients without spasticity,N-acetylaspartate levels in the patients with spasticity were significantly lower in both the precentral gyrus and basal ganglia.Lower N-acetylaspartate levels also correlated with greater sensory and motor dysfunction in the patients who had spinal cord injury with spasticity.

关 键 词：ASIA motor score ASIA sensory score basal ganglia central nervous system duration of injury magnetic resonance spectroscopy N-ACETYLASPARTATE precentral gyrus SPASTICITY spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]