An ultrasound-guided percutaneous electrical nerve stimulation regimen devised using finite element modeling promotes functional recovery after median nerve transection  

作　　者：Xiao-Lei Chu Xi-Zi Song Yu-Ru Li Zi-Ren Wu Qi Li Qing-Wen Li Xiao-Song Gu Dong Ming 

机构地区：[1]Department of Rehabilitation,Tianjin University Tianjin Hospital,Tianjin,China [2]Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin,China [3]College of Exercise&Health Science,Tianjin University of Sport,Tianjin,China [4]College of Precision Instruments and Optoelectronics Engineering,Tianjin University,Tianjin,China

出　　处：《Neural Regeneration Research》2023年第3期683-688,共6页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.81801787(to XZS);China Postdoctoral Science Foundation,No.2018M640238(to XZS);the Natural Science Foundation of Tianjin,No.20JCQNJC01690(to XLC)。

摘　　要：Percutaneous electrical nerve stimulation of an injured nerve can promote and accelerate peripheral nerve regeneration and improve function.When performing acupuncture and moxibustion,locating the injured nerve using ultrasound before percutaneous nerve stimulation can help prevent further injury to an already injured nerve.However,stimulation parameters have not been standardized.In this study,we constructed a multi-layer human forearm model using finite element modeling.Taking current density and activated function as optimization indicators,the optimal percutaneous nerve stimulation parameters were established.The optimal parameters were parallel placement located 3 cm apart with the injury site at the midpoint between the needles.To validate the efficacy of this regimen,we performed a randomized controlled trial in 23 patients with median nerve transection who underwent neurorrhaphy.Patients who received conventional rehabilitation combined with percutaneous electrical nerve stimulation experienced greater improvement in sensory function,motor function,and grip strength than those who received conventional rehabilitation combined with transcutaneous electrical nerve stimulation.These findings suggest that the percutaneous electrical nerve stimulation regimen established in this study can improve global median nerve function in patients with median nerve transection.

关 键 词：finite element modeling median nerve transection nerve regeneration NEUROREHABILITATION percutaneous electrical nerve stimulation peripheral nerve injury randomized controlled trial 

分 类 号：R741[医药卫生—神经病学与精神病学]