卵巢非特异性类固醇细胞瘤病例报道一例并文献复习  

Ovarian steroid cell tumor,not otherwise specified:a case report and review of literature

作　　者：沈艳婷 蒋晶晶 陆志强 Shen Yanting;Jiang Jingjing;Lu Zhiqiang(Department of Endocrinology and Metabolic Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032

出　　处：《中华内分泌代谢杂志》2022年第5期433-436,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文报道1例以高雄激素血症为临床表现,术后病理证实为卵巢非特异性类固醇细胞瘤的病例。患者为绝经后女性,临床表现为"胡须生长、头发稀疏、皮疹、阴蒂增大"。生化提示血睾酮、硫酸脱氢表雄酮、雌二醇升高,黄体生成素、卵泡刺激素降低。影像学见左侧肾上腺低密度小结节及左侧附件区实质占位。完善ACTH兴奋试验、hCG兴奋试验、双侧肾上腺及卵巢静脉采血后,考虑过多的雄激素来源于卵巢。注射促性腺激素释放激素类似物(GnRHa)后,睾酮水平下降至正常范围。后行腹腔镜双附件切除术,病理提示左附件非特异性类固醇细胞瘤。本例报道旨在提高对具有高雄激素临床表现的卵巢非特异性类固醇细胞瘤的认识。We present a case of a postmenopausal women with hyperandrogenic symptoms and virilization signs,such as hirsutism,alopecia,acne and clitoromegaly,which was pathologically confirmed to be an ovarian steroid cell tumor,not otherwise specified(NOS).The levels of testosterone,dehydroepiandrosterone sulfate and estradiol in serum were increased,while the levels of luteinizing hormone and follicle stimulating hormone were decreased.Computed tomography(CT)scan and magnetic resonance imaging(MRI)identified a solid,left ovarian tumor and detected an additional tumor of hypodensity in the left adrenal gland.ACTH stimulation test,hCG stimulation test,adrenal and ovarian vein sampling indicated that excessive androgens were derived from the ovary.After the injection of gonadotropin hormone analogues(GnRHa),testosterone levels dropped to the normal range.Laparoscopic bilateral adnexectomy was performed,and pathology indicated NOS.The purpose of this report is to improve the understanding of NOS with hyperandrogenic presentation.

关 键 词：高雄激素血症 卵巢非特异性类固醇细胞瘤 促性腺激素释放激素类似物 

分 类 号：R737.31[医药卫生—肿瘤]