子宫肌瘤组织中miR-590、miR-16表达的临床意义  

Clinical significance of the expression of miR-590 and miR-16 in hysteromyoma tissue

作　　者：黄燕 周玉珍 潘小虹[2] 朱倩梦 张玉英 HUANG Yan;ZHOU Yuzhen;PAN Xiaohong;ZHU Qianmeng;ZHANG Yuying(Department of Obstetrics and Gynecology,Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu Province,Suzhou 215101,China;Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Soochow University,Jiangsu Province,Suzhou 215100,China)

机构地区：[1]江苏省苏州市中西医结合医院妇产科,江苏苏州215101 [2]苏州大学附属第二医院妇产科,江苏苏州215100

出　　处：《中国医药导报》2022年第20期83-86,共4页China Medical Herald

基　　金：江苏省妇幼健康科研项目(F201730)。

摘　　要：目的探讨子宫肌瘤组织中miR-590、miR-16表达的临床意义。方法选取2018年10月至2020年8月江苏省苏州市中西医结合医院收治的186例子宫肌瘤患者为研究组,并选择同期120例因子宫脱垂实施手术治疗的患者为对照组。采用实时定量PCR检测子宫肌瘤组织与正常子宫组织miR-590、miR-16表达水平;多因素logistic回归分析探讨子宫肌瘤发生的影响因素;采用Pearson相关性分析miR-590、miR-16表达水平与子宫肌瘤大小、数目的关系。结果研究组miR-590表达水平高于对照组,miR-16表达水平低于对照组(P<0.05)。研究组合并糖尿病、月经紊乱、生殖道炎症占比高于对照组,流产次数多于对照组(P<0.05)。logistic回归分析结果显示,月经紊乱,生殖道炎症,子宫组织miR-590、miR-16表达水平是子宫肌瘤发生的影响因素(OR=2.818、2.751、3.888、3.476,P<0.05)。miR-590表达水平与子宫肌瘤大小、数目呈正相关(r=0.767、0.795,P<0.05),miR-16表达水平与子宫肌瘤大小、数目呈负相关(r=-0.743、-0.792,P<0.05)。结论miR-590在子宫肌瘤组织中呈高表达,miR-16则呈低表达,且miR-590、miR-16表达水平与子宫肌瘤的发生相关。Objective To explore clinical significance of the expression of microribonucleic acid-590(miR-590)and miR-16 in hysteromyoma tissue.Methods One hundred and eighty-six patients with hysteromyoma treated in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine,Jiangsu Province from October 2018 to August 2020 were selected as study group,a total of 120 patients with uterine prolapse were selected as the control group.The expression levels of miR-590 and miR-16 in hysteromyoma tissue and normal uterine tissues were detected by real-time quantitative PCR.The influencing factors of hysteromyoma was explored by using multivariate logistic regression analysis.Pearson correlation was used to analyze the relationship between the expression levels of miR-590,miR-16 and the size,number of hysteromyoma.Results The expression level of miR-590 in study group was higher than that in control group,and the expression level of miR-16 was lower than that in control group(P<0.05).The proportion of diabetes mellitus,menstrual disorders,and reproductive tract inflammation in study group were higher than those in control group,the number of miscarriages in study group was more than that in control group(P<0.05).Logistic regression analysis showed that menstrual disorder,genital tract inflammation,and the expression levels of miR-590 and miR-16 in uterine tissue were the influencing factors of hysteromyoma(OR=2.818,2.751,3.888,3.476,P<0.05).The expression level of miR-590 was positively correlated with the size and number of hysteromyomas(r=0.767,0.795,P<0.05).The expression level of miR-16 was negatively correlated with the size and number of hysteromyomas(r=-0.743,-0.792,P<0.05).Conclusion MiR-590 is highly expressed in hysteromyoma tissue while miR-16 is low.The expression levels of miR-590 and miR-16 are related to the occurrence of hysteromyoma.

关 键 词：miR-590 miR-16 子宫肌瘤 肌瘤直径 肌瘤数目 

分 类 号：R737.33[医药卫生—肿瘤]