啮齿类动物衰弱模型研究进展  

Research progress on rodent frailty models

作　　者：刘盼 李耘[1] 马丽娜[1] Liu Pan;Li Yun;Ma Lina(Department of Geriatrics,Xuanwu Hospital,Capital Medical University,National Clinical Research Center for Geriatric Diseases,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院老年医学科,国家老年疾病临床研究中心,北京100053

出　　处：《中华老年医学杂志》2022年第7期872-876,共5页Chinese Journal of Geriatrics

基　　金：北京市自然科学基金(7202059)。

摘　　要：衰弱是一种常见的老年综合征,常表现为机体多系统功能下降、储备功能减退,更易发生健康不良事件,影响老年人的生命质量。但衰弱可能的潜在机制尚不明确。啮齿类动物与人类具有同源性,是研究人类疾病常用的动物模型。因此,啮齿类动物衰弱模型有助于促进人类衰弱的研究和干预。本文就啮齿类动物衰弱模型研究进展做一综述。Frailty is a geriatric syndrome characterized by declines in multisystem functions,decreased functional reserve,and increased vulnerability to adverse health events,and affects the quality of life in older adults.However,the underlying mechanisms of frailty are still unclear.Rodents share homology with humans and are commonly used as animal models to study human diseases.Rodent frailty models can promote frailty research and intervention in humans.We reviewed research progress on rodent frailty models in this article.

关 键 词：衰弱 啮齿类动物 动物模型 

分 类 号：R-332[医药卫生] R592