m6A修饰在骨肉瘤中分子机制的研究进展  

Research Progress on the Molecular Mechanism of m6A Modification in Osteosarcoma

作　　者：凌志安[1] 梁玉婷 韦素萍 王禹 赵劲民[2] LING Zhi′an;LIANG Yuting;WEI Suping;WANG Yu;ZHAO Jinmin(The Second Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi,530007,China;Guangxi Medical University,Nanning,Guangxi,530021,China)

机构地区：[1]广西医科大学第二附属医院,广西南宁530007 [2]广西医科大学,广西南宁530021

出　　处：《广西科学》2022年第3期423-429,共7页Guangxi Sciences

基　　金：广西自然科学基金项目(2019JJA140546);广西壮族自治区中青年教师基础能力提升项目(2019KY0117)资助。

摘　　要：N6-甲基腺苷(m6A)是真核生物mRNA中最丰富的表观遗传修饰之一,在多种疾病尤其是肿瘤中发挥重要作用。m6A修饰受到甲基转移酶、去甲基化酶和RNA结合蛋白的动态调控。骨肉瘤是一种好发于儿童和青少年的恶性骨肿瘤之一,近年来骨肉瘤发生率呈上升趋势,m6A修饰的调控表达与骨肉瘤的发生发展及预后相关。本文就m6A修饰在骨肉瘤发生发展、化疗耐药、靶向治疗、预后转归的分子机制方面的研究进行综述,旨在为骨肉瘤的早期诊断和靶向治疗提供新思路。N6-methyladenosine(m6A)is one of the most abundant epigenetic modifications in eukaryotic mRNA and plays an important role in many diseases,especially tumors.Modification of m6A is dynamically regulated by methyltransferases,demethylases,and RNA-binding proteins.Osteosarcoma is one of the malignant bone tumors that are prone to occur in children and adolescents.In recent years,the incidence of osteosarcoma has increased.The regulated expression of m6A is related to the occurrence,development and prognosis of osteosarcoma.The research progress of the molecular mechanism of m6A modification in the occurrence and development of osteosarcoma,chemo-resistance,targeted therapy and prognosis are reviewed in this article to provide new ideas for the early diagnosis and targeted therapy of osteosarcoma.

关 键 词：m6A RNA甲基化 骨肉瘤 进展及预后 分子机制 

分 类 号：R78.6[医药卫生—口腔医学]