胃癌患者Hp感染与临床病理特征、肿瘤标志物水平及癌基因表达的相关性研究  

Correlation between Hp infection with clinicopathological features,tumor markers,oncogene expression in patients with gastric cancer

作　　者：刘登海 LIU Deng-hai(Yuncheng County People's Hospital Laboratory,Heze 274700,China)

机构地区：[1]郓城县人民医院检验科,山东菏泽274700

出　　处：《中国处方药》2022年第7期130-132,共3页Journal of China Prescription Drug

摘　　要：目的研究胃癌患者幽门螺杆菌(Hp)感染与临床病理特征、肿瘤标志物水平、癌基因表达的相关性。方法选择2018年2月~2021年3月期间在某院手术切除的180例胃癌患者,采集患者的临床病理特征,采集血清后测定肿瘤标志物水平,收集胃癌病灶及癌旁病灶后测定Hp感染情况、癌基因表达量。结果180例胃癌组织的Hp感染率为56.67%;TNMⅢ期和TNMⅡ期的胃癌组织中Hp感染率明显高于TNMⅠ期且TNMⅢ期的胃癌组织中Hp感染率明显高于TNMⅡ期;低分化的胃癌组织中Hp感染率明显高于中高分化;浸润深度T_(3)+T_(4)的胃癌组织中Hp感染率明显高于浸润深度T_(1)+T_(2);胃癌组织中Hp阳性患者的血清CEA、CA19-9、VEGF的水平均明显高于胃癌组织中Hp阴性的患者,PGR的水平明显低于胃癌组织中Hp阴性的患者;Hp阳性的胃癌组织中c-myc、c-Met、Bmi-1的mRNA表达量明显高于Hp阴性的胃癌组织,GKN1、p16的mRNA表达量明显低于Hp阴性的胃癌组织。结论胃癌患者Hp感染与临床病理特征改变、肿瘤标志物的水平增多、癌基因表达异常有关。Objective To study the correlation between Helicobacter pylori(Hp)infection with clinicopathological features,tumor markers,oncogene expression in patients with gastric cancer.Methods 180 gastric cancer patients who underwent surgical resection in our hospital from February 2018 to March 2021 were selected.The clinicopathological characteristics of the patients were collected.The content of tumor markers was measured after serum collection.The Hp infection and oncogene expression were measured after the collection of gastric cancer lesions and adjacent lesions.Results The Hp infection rate in 180 cases of gastric cancer was 56.67%;the Hp infection rate in TNM stageⅢand TNM stageⅡwas significantly higher than that in TNM stageⅠand the Hp infection rate in TNM stageⅢwas significantly higher than that in TNM stageⅡ;the Hp infection rate in poorly differentiated gastric cancer was significantly higher than that in moderately differentiated gastric cancer;the Hp infection rate in gastric cancer tissues with depth of T_(3)+T_(4) was significantly higher than that of T_(1)+T_(2).The levels of serum CEA,CA19-9 and VEGF in patients with Hp-positive gastric cancer tissues were significantly higher than those in patients with Hp-negative gastric cancer tissues,the level of PGR was significantly lower than those in patients with Hp-negative gastric cancer tissues;the mRNA expression of c-myc,c-Met and Bmi-1 in Hp-positive gastric cancer tissues were significantly higher than those in Hp-negative gastric cancer tissues;the mRNA expression of GKN1 and p16 were significantly lower than those in Hp-negative gastric cancer tissues.Conclusion Hp infection in patients with gastric cancer correlates with the changes of clinicopathological features,the increase of tumor markers and abnormal expression of oncogene.

关 键 词：胃癌 幽门螺杆菌 肿瘤标志物 癌基因 

分 类 号：R735.2[医药卫生—肿瘤]