利培酮联合不同剂量艾司西酞普兰对精神分裂症患者社会功能的影响  

Effects of risperidone combined with different doses of Escitalopram on social function in patients with schizophrenia

作　　者：裘建萍 陆峥[2] 班春霞[3] 黄昱淳 沈凯[1] 李泽兵[1] QIU Jianping;LU Zheng;BAN Chunxia(Shanghai Putuo District Mental Health Center,Shanghai 200065,China)

机构地区：[1]上海市普陀区精神卫生中心,上海200065 [2]上海市精神卫生中心 [3]上海市嘉定区精神卫生中心

出　　处：《国际精神病学杂志》2022年第3期436-439,450,共5页Journal Of International Psychiatry

基　　金：上海市普陀区卫生系统自主创新科研资助项目(编号:01.02.06d-2018-010)。

摘　　要：目的 探讨利培酮联合不同剂量艾司西酞普兰对精神分裂症患者社会功能的影响方法 选择101例精神分裂症患者,随机分为A组(34例)、B组(23例)、C组(22例)、D组(22例)。A组单用利培酮治疗,B、C、D组分别为利培酮联合5mg、10mg、15mg艾司西酞普兰治疗,观察12周。采用重复测量方差分析比较四组在治疗前后阳性与阴性症状量表(Positive And Negative Syndrome Scale,PANSS)、阴性症状评估量表(Scale for Assessment of Negative Symptoms,SANS)、个人社会功能量表(Personal and Social Performance Scale,PSP)评分;比较副反应量表(Treatment Emergent Symptom Scale,TESS)评分。结果 PANSS、SANS、PSP评分的组别与时间交互作用无统计学意义(F=0.602,F=1.750,F=3.610,P=0.700,P=0.132,P=0.211);PANSS,SANS评分在时间主效应上具有统计学意义(F=445.619,F=228.348,P=0.001,P=0.001),且四组在不同时间点的差异具有统计学意义(P<0.05),并随时间增加,PANSS、SANS评分降低。SANS评分在组别主效应上具有统计学意义(F=4.108,P=0.009),在第4周末四组剂量的差异均具有统计学意义。LSD法两两比较发现,B组SANS评分低于A、C、D组(P=0.001,P=0.016,P=0.002);PSP评分在组别主效应上具有统计学意义(F=3.589,P=0.003),在第4周末四组剂量的差异具有统计学意义,两两比较发现,B组PSP评分高于C、D组(P=0.001,P=0.001)。四组在不良反应发生率上,差异无统计学意义(χ^(2)=0.566,P<0.05)。结论 利培酮联合5mg艾司西酞普兰总体疗效更优,不良反应相对较低,对患者社会功能恢复具有较高临床价值。Objective To investigate the effect of risperidone combined with different doses of escitalopram on social function in patients with schizophrenia.Methods A total of 101 patients with schizophrenia were selected.They were randomly divided into group A(34 cases),group B(23 cases),group C(22 cases)and group D(22 cases).Group A was treated with risperidone alone.Group B,C and D were treated with risperidone combined with 5 mg,10 mg and 15 mg escitalopram respectively.All patients were followed up for 12 weeks.The scores of Positive and Negative Symptom Scale(PANSS),Negative Symptom Assessment Scale(SANS)and Personal Social Function Scale(PSP)before and after treatment were compared by repeated ANOVA.The side effects scale(TESS)scores were compared.Results PANSS,SANS and PSP scores showed no significant interaction between group and time(F=0.602,F=1.750,F=3.610,P=0.700,P=0.132,P=0.211).PANSS and SANS scores were statistically significant in the time main effect(F=445.619,F=228.348,P=0.001,P=0.001),and the differences among the four groups at different time points were statistically significant(P<0.05),and PANSS and SANS scores decreased with the increase of time.SANS score was statistically significant in the main effect of the group(F=4.108,P=0.009).At the end of the fourth week,there were statistically significant differences in the doses of the four groups.The SANS scores in group B were lower than those in groups A,C and D(P=0.001,P=0.016,P=0.002).PSP score was statistically significant in the main effect of the group(F=3.589,P=0.003).At the end of the fourth week,the differences of doses between the four groups were statistically significant.Pair comparison showed that PSP score of group B was higher than that of group C and D(P=0.001,P=0.001).There was no statistical significance in the incidence of adverse reactions among the four groups(χ^(2)=0.566,P<0.05).Conclusion Risperidone combined with 5mg escitalopram had better overall curative effect,lower adverse reactions and higher clinical value for the recover

关 键 词：精神分裂症 阴性症状 社会功能 艾司西酞普兰 利培酮 

分 类 号：R749.05[医药卫生—神经病学与精神病学]