肝肿瘤切除术与射频消融术治疗原发性肝癌的疗效及其对血清AFP、CEA、CA125水平的影响  

Efficacy of Liver Tumor Resection Versus Radiofrequency Ablation for Primary Liver Cancer and the Effect on Serum AFP,CEA,and CA125 Levels

作　　者：张贻庆[1] 崔贵医 杨磊[1] 刘刚[1] 冯世杰 王劲[1] ZHANG Yiqing;CUI Guiyi;YANG Lei(Jiaozuo People's Hospital,Jiaozuo,454000)

机构地区：[1]河南省焦作市人民医院,454000

出　　处：《实用癌症杂志》2022年第8期1316-1319,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划(编号:LHGJ20191336)。

摘　　要：目的对比分析肝肿瘤切除术与射频消融治疗原发性肝癌的效果及其对血清甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原125(CA125)水平的影响。方法选取原发性肝癌患者102例,采用随机数分组法将其分成常规组和研究组,各51例。常规组患者接受肝肿瘤切除术治疗,研究组患者进行射频消融治疗术治疗。在术前1天及术后d 7评定2组患者血清学指标、凝血功能,随访1年评定2组患者临床疗效,统计其并发症。结果术前1天2组患者血清AFP、CEA、CA125水平差异比较无统计学意义(P>0.05);术后d7研究组患者血清AFP(96.57±8.54)μg/L、CEA(10.78±2.06)μg/L、CA125(19.87±3.16)kU/mL,均低于常规组(P<0.05)。研究组临床总有效率高于常规组(P<0.05)。术前1天2组患者D-二聚体(D-D)和凝血酶原时间(PT)差异比较无统计学意义(P>0.05);术后d7研究组患者D-D(1.06±0.21)μg/ml、PT(7.27±1.06)s,均低于常规组(P<0.05)。研究组患者并发症总发生率低于常规组(P<0.05)。结论射频消融术治疗原发性肝癌相较于肝肿瘤切除术,临床疗效较好、相关血清标志物水平下降更显著,推荐使用。Objective To compare the efficacy of liver tumor resection versus radiofrequency ablation for primary liver cancer and the effect on serum alpha fetoprotein(AFP),carcinoembryonic antigen(CEA),and carbohydrate antigen 125(CA125)levels.Methods 102 patients with primary liver cancer diagnosed and treated were selected,and divided into 2 groups by random number table method,each with 51 cases.Control group received liver tumor resection,while study group received radiofrequency ablation.The serological parameters and coagulation function indexes were detected at preoperative 1d and postoperative 7d.Patients were followed up for 1 year,and the clinical efficacy and complications were evaluated during that period.Results Serum levels of AFP,CEA and CA125 at preoperative 1d yielded no statistical difference between the 2 groups(P>0.05).Serum levels of AFP,CEA and CA125 at postoperative 7d were(96.57±8.54)μg/L,(10.78±2.06)μg/L and(19.87±3.16)kU/mL in study group,which were significantly lower than those of control group(P<0.05).The clinical efficacy rate of study group was significantly higher than that of control group(P<0.05).D-dimer(D-D)and prothrombin time(PT)at preoperative 1d demonstrated no significant difference between two groups(P>0.05),while the 2 parameters were(1.06±0.21)μg/ml and(7.27±1.06)s in study group at postoperative 7d,which were significantly lower than those of control group(P<0.05).The overall incidence rate of complications in study group was significantly lower than that of control group(P<0.05).Conclusion Compared with liver tumor resection,application of radiofrequency ablation in the treatment of primary liver cancer achieves better clinical efficacy and liver function.

关 键 词：肝肿瘤切除术 射频消融术 原发性肝癌 疗效 AFP CEA CA125 

分 类 号：R735.7[医药卫生—肿瘤]