新辅助治疗后血清miR-448和miR-143水平对胰腺癌患者术后生存和预后的影响  

Effects of Serum miR-448 and miR-143 Levels After Neoadjuvant Therapy in Patients with Pancreatic Cancer on Postoperative Outcome and Prognosis

作　　者：李秀明[1] 刘璐[1] 万琼[1] 张珉[2] LI Xiuming;LIU Lu;WAN Qiong(Zhengzhou People's Hospital,Zhengzhou,450000)

机构地区：[1]郑州人民医院,450000 [2]河南省肿瘤医院,450000

出　　处：《实用癌症杂志》2022年第8期1331-1334,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20190628)。

摘　　要：目的探究胰腺癌患者新辅助治疗后血清miR-448和miR-143水平对术后生存和预后的影响。方法选取胰腺癌患者的60例,RT-PCR检测新辅助治疗后血清miR-448和miR-143水平,并探究其与术后生存和预后的关系。结果胰腺癌患者的年龄、肝转移、KPS评分、CA19-9水平以及miR-448和miR-143水平与患者中位生存期显著相关(P<0.05)。miR-448水平、miR-143水平、肝转移、KPS评分、CA19-9水平是胰腺癌患者预后的影响因素(P<0.05)。肝转移、KPS评分、CA19-9水平、miR-448水平、miR-143水平评估胰腺癌患者生存结局的预测价值AUC分别为0.743,0.712,0.802,0.754,0.763。结论肝转移、KPS评分、CA19-9水平、miR-448水平、miR-143水平是胰腺癌患者预后的独立影响因素,具有对胰腺癌患者术后生存结局的预测价值。Objective To explore the effects of serum miR-448 and miR-143 levels after neoadjuvant therapy in patients with pancreatic cancer on postoperative outcomes and prognosis.Methods A total of 60 patients with pancreatic cancer were selected.The serum miR-448 and miR-143 levels after neoadjuvant therapy were detected by RT-PCR,and their relationship with the postoperative outcome was explored.Relationship with prognosis.Results The age,liver metastasis,KPS score,CA19-9 level,and miR-448 and miR-143 levels of patients with pancreatic cancer were significantly correlated with the median survival of patients(P<0.05).The level of miR-448,miR-143,liver metastasis,KPS score,and CA19-9 level are the prognostic factors of patients with pancreatic cancer(P<0.05).The predictive value of liver metastasis,KPS score,CA19-9 level,miR-448 level,and miR-143 level in assessing the survival outcome of patients with pancreatic cancer AUC were 0.743,0.712,0.802,0.754,0.763,respectively.Conclusion Liver metastasis,KPS score,CA19-9 level,miR-448 level,and miR-143 level are independent factors affecting the prognosis of patients with pancreatic cancer,and have predictive value for the survival outcome of patients with pancreatic cancer.

关 键 词：胰腺癌 新辅助治疗 miR-448 MIR-143 术后结局 预后 

分 类 号：R735.9[医药卫生—肿瘤]