沉默信息调节因子3对颞下颌关节骨关节炎的影响  

Effect of silence information regulator 3 on temporomandibular joint osteoarthritis

作　　者：杨毓芝 俞燕芳[1] 吴梦婕[1] Yang Yuzhi;Yu Yanfang;Wu Mengjie(Department of Orthodontics,Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine&Clinical Research Center for Oral Diseases of Zhejiang Province&Key Laboratory of Oral Biomedical Research of Zhejiang Province&Cancer Center of Zhejiang University,Hangzhou 310006,China)

机构地区：[1]浙江大学医学院附属口腔医院正畸科·浙江大学口腔医学院,浙江省口腔疾病临床医学研究中心,浙江省口腔生物医学研究重点实验室,浙江大学癌症研究院,杭州310006

出　　处：《中华口腔医学杂志》2022年第7期756-761,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(81970956)。

摘　　要：颞下颌关节骨关节炎(temporomandibular joint osteoarthritis,TMJOA)是颞下颌关节紊乱病中常见的一种,其发病原因复杂且治疗方式有限。TMJOA在发生关节区炎症的同时可导致髁突骨赘形成、关节面硬化、糜烂、软骨下骨囊肿等颞下颌关节(temporomandibular joint,TMJ)结构变化。目前研究发现表观遗传调控能影响TMJ生长发育以及调控免疫炎症反应,因此推测TMJOA的发生发展中有表观遗传修饰的参与。本文综述表观遗传中重要因子沉默信息调节因子3(silence information regulator 3,SIRT3)在骨关节炎及风湿性关节炎领域的相关研究,探讨SIRT3介导的乙酰化修饰对软骨、滑膜、骨及血管等TMJ结构生长发育的影响,并推测SIRT3在缓解骨关节炎和滑膜炎等方面的作用,从而完善对TMJOA发病机制的认识,为临床治疗提供新思路。Temporomandibular joint osteoarthritis(TMJOA)is a common subclass of temporomandibular disorders,with complicated causes and limited treatment.In addition to inflammatory reaction,structural changes of temporomandibular joint(TMJ)as condylar osteophyte formation,sclerosis,erosion,and subchondral bone cysts will happen at the same time.At present,it is found that epigenetic regulation can affect the growth and development of TMJ and regulate the immune inflammatory reaction,so we can speculate that epigenetic modification is involved in the occurrence and development of TMJOA.This paper reviews the researches of silence information regulator 3(SIRT3),which is a key factor in epigenetics,in the field of osteoarthritis and rheumatoid arthritis.In order to discuss the effect of SIRT3 on the growth and development of TMJ by mediating acetylation modification,such as bone,cartilage,synovium and blood vessels,as well as alleviating osteoarthritis and synovitis.By doing this,the understanding of TMJOA can be enriched,with the goal of finding a new possibility for the clinical treatment of TMJOA.

关 键 词：颞下颌关节 颞下颌关节紊乱病 表观遗传学 乙酰化修饰 沉默信息调节因子3 

分 类 号：R782.6[医药卫生—口腔医学]