颅内动脉延长与扩张症的研究进展  

Progress in the study of intracranial arterial dolichoectasia

作　　者：汪训粉 张敏[2] 马阳 曹音[2] 恽文伟[2] Wang Xunfen;Zhang Min;Ma Yang;Cao Yin;Yun Wenwei(Graduate School of Dalian Medical University,Dalian 116044,China;Department of Neurology,Changzhou Second People′s Hospital Affiliated to Nanjing Medical University,Changzhou 213003,China)

机构地区：[1]大连医科大学研究生院,大连116044 [2]南京医科大学附属常州市第二人民医院神经内科,常州213003

出　　处：《中华神经科杂志》2022年第7期788-793,共6页Chinese Journal of Neurology

基　　金：江苏省卫生健康委面上项目(H2019051);常州市卫生健康青苗人才培养工程(CZQM2020073)。

摘　　要：颅内动脉延长与扩张症(IADE)亦称扩张性脑动脉病,表现为一支或者多支颅内动脉长度和直径增加,受累的动脉明显扩张延长,甚至蜿蜒迂曲。IADE的诊断和预后评估主要依据颅内动脉的直径及弯曲度。IADE可表现为缺血性脑卒中、短暂性脑缺血发作、脑积水、出血性卒中等。文中就IADE的概念、诊断标准、病因、发病机制、病理、临床表现、治疗及预后等方面进行综述。Intracranial arterial dolichoectasia(IADE),also known as dilated cerebral artery disease,is manifested as an increase in the length and diameter of one or more intracranial arteries,the affected arteries being enlarged and dilated significantly,or even with winding and tortuosity.The diagnosis and prognostic evaluation of IADE are mainly based on the diameter and curvature of the intracranial artery.IADE can be manifested as ischemic stroke,transient ischemic attack,hydrocephalus,and hemorrhagic stroke.The review focuses on IADE,including the concept,diagnostic criteria,etiology,pathogenesis,pathology,clinical manifestations,treatment,and prognosis.

关 键 词：颅内动脉疾病 动脉粥样硬化 基质金属蛋白酶类 卒中 颅内动脉延长与扩张 

分 类 号：R743[医药卫生—神经病学与精神病学]