NLRP3在支气管哮喘"肺-脑轴"免疫炎症中的作用研究进展  

Research progress on the role of NLRP3 in the immune inflammation of the"lung-brain axis"of bronchial asthma

作　　者：李春霞 周浩[2] 崔玉霞 Li Chunxia;Zhou Hao;Cui Yuxia(Graduate School of Zunyi Medical University,Zunyi 563000,China;Department of Pediatrics,Guizhou Provincial People′s Hospital,Guiyang 550002,China)

机构地区：[1]遵义医科大学研究生院,遵义563000 [2]贵州省人民医院儿科,贵阳550002

出　　处：《中华实用儿科临床杂志》2022年第13期1037-1040,共4页Chinese Journal of Applied Clinical Pediatrics

基　　金：贵州省人民医院国家自然基金培育基金(黔科合平台人才(2018)5764-02)。

摘　　要：支气管哮喘(哮喘)是儿童时期最常见的慢性病。临床诊疗中发现,部分哮喘患儿常合并不同程度的神经精神疾病,如孤独症谱系障碍、注意缺陷-多动障碍、恐慌症及焦虑等,这给哮喘预后及治疗带来很大困难。部分报道提示,支气管哮喘"肺-脑轴"的关联在于炎症相关机制的暴发,通过抑制炎症因子释放,阻止肺-脑间炎症的沟通可能成为改善哮喘并发神经精神疾病的新思路。NOD样受体热蛋白结构域相关蛋白3(NLRP3)作为研究较多的炎症小体家族成员之一,广泛参与在神经炎症与哮喘发作的机制中,现对NLRP3在哮喘"肺-脑轴"免疫炎症机制中的作用相关报道进行综述,为哮喘与神经精神共患病的攻克提供新的诊疗及研究思路。Bronchial asthma is the most common chronic disease in childhood.In clinical diagnosis and treatment,it is found that some children with asthma often have neuropsychiatric disorders of different severity,such as autism spectrum disorders,attention deficit-hyperactivity disorders,panic disorders and anxiety,which render the prognosis and treatment of asthma difficult.Some reports suggest that the"lung-brain axis"of bronchial asthma is related to the outbreak of inflammation-related mechanisms.A new idea to improve bronchial asthma with neuropsychiatric diseases may be inhibiting the release of inflammatory factors and blocking lung-brain inflammation communication.As one of the more thoroughly studied inflammasome family members,NOD-like receptor pyrin domain-containing protein 3(NLRP3)is widely involved in the mechanisms of neuroinflammation and bronchial asthma attacks.In this article,the role of NLRP3 in the"lung-brain axis"immune inflammation mechanism of bronchial asthma is reported,which may provide new ideas for the diagnosis,treatment and research of bronchial asthma and neuropsychiatric comorbidities.

关 键 词：NLRP3 支气管哮喘 肺-脑轴 免疫炎症 

分 类 号：R725.6[医药卫生—儿科]