阳和汤治疗恶性肿瘤的研究进展  

Research progress of Yanghe decoction for the treatment of malignant tumors

作　　者：韩懿存 武颖烁 尚艺婉 陈玉龙[1,2] HAN Yicun;WU Yingshuo;SHANG Yiwan;CHEN Yulong(Graduate School of Henan University of Chinese Medicine,Zhengzhou 450046;China.2.Henan Key Laboratory of TCM Syndrome and Prescription in Signaling,Henan International Joint Laboratory of TCM Syndrome and Prescription in Signaling,Academy of Chinese Medical Sciences,Henan University of Chinese Medicine,Zhengzhou 450046)

机构地区：[1]河南中医药大学研究生院,郑州450046 [2]河南中医药大学中医药科学研究院河南省中医方证信号传导重点实验室/河南省中医方证信号传导国际联合重点实验室,郑州450046

出　　处：《中国比较医学杂志》2022年第7期109-117,共9页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金面上项目(81873285,82074313)。

摘　　要：阳和汤出自清代《外科全生集》,功在温阳补血,散寒通滞。中医认为阳虚寒痰凝聚是恶性肿瘤发病的重要机制,阳和汤作为温阳散寒通滞的代表方之一,临床上治疗恶性肿瘤应用广泛,尤其在诸多“阳虚型”癌症患者中疗效显著,基于此,文章对2001~2021年CNKI、万方数据、维普、SinoMed中国生物医学文献系统、PubMed、Medline、Embase数据库以“阳和汤、温阳法、恶性肿瘤(癌症)、网络药理学”为主题进行检索,共检索文献225篇,整理、归纳相关文献94篇,主要从中医的理论渊源、临床观察、药理研究等方面对阳和汤的作用机制进行概述,同时结合网络药理学进一步探析其应用于恶性肿瘤的可行性,以期为恶性肿瘤的临床治疗提供科学依据。Yanghe decoction is derived from the Qing Dynasty “Waike Quan sheng ji”, which has the effect of warming Yang and replenishing blood, dispersing cold and clearing stagnation. In accordance with traditional Chinese medicine, Yang deficiency and cold phlegm condensation are major mechanisms of malignant tumors. As a representative prescription of warming Yang and dispersing cold and stagnation, Yanghe decoction is widely used in the clinical treatment of malignant tumor, especially in Yang-deficient cancer patients. We analyzed CNKI, WanFang, VIP, SinoMed Chinese Biomedical Literature System, PubMed, Medline and Embase database from 2001 to 2021, found 225 articles with the topics of “Yanghe decoction, warming Yang method, malignant tumor(cancer), and network pharmacology”, and sorted out, and summarized 94 relevant articles. This review summarizes the mechanism of Yanghe decoction from the aspects of their theoretical origin, clinical observations, and pharmacological research to provide a scientific basis for the clinical treatment of malignant tumors.

关 键 词：阳和汤 恶性肿瘤 寒痰凝聚 机制 网络药理学 

分 类 号：R-33[医药卫生]