PTEN基因在周围神经损伤修复中的作用机制研究进展  

Research progress on the mechanism of PTEN in the repair of peripheral nerve injury

作　　者：褚云峰[1] 于红燕 杨琪 彭艳斌[1] 陈仲 于斐[1,3] CHU Yunfeng;YU Hongyan;YANG Qi;PENG Yanbin;CHEN Zhong;YU Fei(Peking University Shenzhen Hospital,Shenzhen 518036,China;Binchengqu Shili Hospital,Binzhou 256600;National&Local Joint Engineering Research Center of Orthopaedic Biomaterials,Shenzhen 518036)

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]滨州市滨城区市立医院,山东滨州256600 [3]骨科生物材料国家地方联合工程研究中心,广东深圳518036

出　　处：《中国比较医学杂志》2022年第7期124-130,136,共8页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82102568,82102076,82172432,82001319);广东省基础与应用基础研究基金(2021A1515012586,2019A1515110983,2019A1515011290);白求恩·石药骨质疏松科研基金项目(G-X-2020-1107-21);北京大学深圳医院科研启动金项目(KYQD2021099)。

摘　　要：周围神经损伤是影响人类健康的重大疾病之一,由于该病损伤修复机制阐述不明,使其治疗效果不佳,也因此成为临床领域骨科医生的治疗难点。近年来,第10号染色体缺失的磷酸酶及张力蛋白同源基因(phosphatase and tensin homologue deleted on chromosome 10,PTEN)在周围神经损伤修复中研究较多,本文就PTEN基因通过调控周围神经损伤后的突触再生、炎性及免疫反应、神经元凋亡、神经营养相关因子等过程以及核因子-κB(NF-κB)、磷脂酰肌醇激酶/蛋白激酶B/雷帕霉素靶蛋白(PI3K/AKT/mTOR)、非受体酪氨酸激酶/信号传导及转录激活蛋白(Jak/stat)、丝裂原活化蛋白激酶(MAPK)等信号通路的作用影响周围神经损伤后的修复进程作一综述,为相关研究提供便利。Peripheral nerve injury is a major disease. Because the injury and repair mechanisms of the disease are unclear, its treatment is poor. Therefore, peripheral nerve injury has become a difficult point for orthopedics doctors. In recent years, phosphatase and tensin homologue deleted on chromosome 10(PTEN) has been widely studied to repair peripheral nerve injury. Here, we review the mechanism of PTEN in regulating synaptic regeneration, inflammatory and immune responses, neuronal apoptosis, neurotrophic related factors, and NF-κB, PI3 K/AKT/mTOR and Jak/Stat signaling pathways during the repair of peripheral nerve injury to facilitate research.

关 键 词：周围神经损伤修复 第10号染色体缺失的磷酸酶及张力蛋白同源基因 作用机制 

分 类 号：R-33[医药卫生]