缺血-再灌注氧化损伤机制及其对不同器官功能的影响  

Oxidative injury mechanism of ischemia-reperfusion and its effect on various organ functions

作　　者：李昕 王芷宁 付璐 张林波[1,2] 肖盛元 张文慧[1] LI Xin;WANG Zhining;FU Lu;ZHANG Linbo;XIAO Shengyuan;ZHANG Wenhui(College of Life Sciences,Jilin Agricultural University,Changchun 130118,China;Engineering Research Center of Edible and Medicinal Fungi,Ministry of Education,Jilin Agricultural University,Changchun 130118;College of Chinese Materia Medica,Jilin Agricultural University,Changchun 130118;National and Local Joint Engineering Research Center of Remote Breeding and Development of Ginseng New Varieties,Changchun 130118)

机构地区：[1]吉林农业大学生命科学学院,长春130118 [2]吉林农业大学食药用菌教育部工程研究中心,长春130118 [3]吉林农业大学中药材学院,长春130118 [4]人参新品种远育与开发国家地方联合工程技术研究中心,长春130118

出　　处：《中国比较医学杂志》2022年第7期149-154,共6页Chinese Journal of Comparative Medicine

基　　金：吉林省科技发展计划重点研发项目(20210202084NC)。

摘　　要：缺血是由于机体组织器官梗死或者血液供应障碍等原因造成的一种局限性缺血性坏死或软化,常发生在肝、肾、脑等器官。在恢复血流供应的初期,往往会引起“缺血-再灌注损伤(ischemia reperfusion injury,IRI)”。氧化应激是诱发缺血-再灌注损伤的重要原因之一,相关研究证实缺血-再灌注氧化损伤会导致活性氧(reactive oxygen species,ROS)产生,而ROS可相应引起器官损伤及功能障碍。本综述主要从氧化应激角度对近些年来有关缺血-再灌注氧化损伤的研究进展进行总结,分析这种损伤对各组织器官的影响,旨在进一步揭示缺血-再灌注氧化损伤机制,为相应疾病的预防和治疗提供思路。Ischemia is a kind of localized ischemic necrosis or softening caused by infarction of tissues and organs or blood supply disturbance, which often occurs in the liver, kidney, brain, and other organs. In the early stage of restoring blood supply, it often causes ischemia-reperfusion injury. Oxidative stress is a major causes of ischemia-reperfusion injury. Studies have confirmed that ischemia-reperfusion leads to the production of reactive oxygen species, which causes organ injury and dysfunction. This review summarizes the research progress of ischemia-reperfusion oxidative injury in recent years from the perspective of oxidative stress and analyzes the effect of this injury on various tissues and organs. It aims to further reveal the mechanism of oxidative injury caused by ischemia-reperfusion and provide ideas for the prevention and treatment of related diseases.

关 键 词：缺血再灌注 氧化损伤 活性氧 器官 

分 类 号：R-33[医药卫生]