子宫内膜癌中雌孕激素受体、Ki-67、C-erbB-2表达与病理的相关性分析  

Correlation Analysis of the Expression of Estrogen and Progesterone Re⁃ceptor,Ki-67,C-erbB-2 and Pathology in Endometrial Carcinoma

作　　者：张跃 ZHANG Yue(Department of Pathology,Shanghe County People's Hospital,Shanghe,Shandong Province,251600 China)

机构地区：[1]商河县人民医院病理科,山东商河251600

出　　处：《系统医学》2022年第11期26-30,共5页Systems Medicine

摘　　要：目的分析子宫内膜癌(endometrial carcinoma,EC)中孕激素受体(PR)、雌激素受体(ER)、表皮生长因子受体2(C-erbB-2)与增殖细胞核抗原67(Ki-67)表达与病理的相关性。方法选取2020年8月-2021年7月商河县人民医院收治的52例EC患者作为研究组。另选48例子宫内膜不典型增生患者作为对照组。检测两组患者的病灶组织中的ER、PR、Ki-67、C-erbB-2表达情况。比较不同临床病理特征研究组EC患病灶组织中ER、PR、Ki-67、C-erbB-2阳性表达率。结果研究组ER、PR阳性表达率为53.85%、50.00%,低于对照组(83.33%、83.33%),差异有统计学意义(χ^(2)=9.974、12.359,P<0.05),Ki-67、C-erbB-2阳性表达率(76.92%、75.00%)高于对照组(20.83%、25.00%),差异有统计学意义(χ^(2)=31.410、24.970,P<0.05)。研究组EC患者病理分期Ⅲ~Ⅳ期、肌层浸润程度≥1/2、中低分化、有淋巴结转移的ER阳性表达率为22.73%、29.63%、43.27%、25.00%,PR阳性表达率为22.73%、25.93%、37.84%、25.00%,低于Ⅰ~Ⅱ期、肌层浸润程度<1/2、高分化与无淋巴结转移者(76.67%、80.00%、80.00%、71.88%;70.00%、76.00%、80.00%、65.63%),差异有统计学意义(χ^(2)=14.859、13.252、5.802、10.882、11.346、13.019、7.589、8.125,P<0.05)。研究组EC患者病理分期Ⅲ~Ⅳ期、肌层浸润程度≥1/2、中低分化、有淋巴结转移的Ki-67阳性表达率(95.45%、96.30%、94.59%、95.00%)与C-erbB-2阳性表达率(95.45%、100.00%、89.19%、95.00%)高于Ⅰ~Ⅱ期、肌层浸润程度<1/2、高分化与无淋巴结转移者(63.33%、56.00%、33.33%、65.63%;60.00%、48.00%、40.00%、62.50%),差异有统计学意义(χ^(2)=7.377、11.874、22.565、5.983、8.509、18.720、13.773、6.933,P<0.05)。经Spearman相关性分析显示,ER、PR与EC患者病理特征呈负相关性(P<0.05),Ki-67、C-erbB-2与EC患者病理特征呈正相关性(P<0.05)。结论EC患者病灶组织中ER、PR、Ki-67、C-erbB-2表达与病理密切相关。Objective To analyze progesterone receptor(PR),estrogen receptor(ER),epidermal growth factor recep⁃tor 2(C-erbB-2)and proliferating cell nuclear antigen 67(Ki-67)in endometrial cancer Correlation of expression with pathology.Methods A total of 52 endometrial carcinoma(EC)patients admitted to the Shanghe County People's Hospital from August 2020 to July 2021 were selected as the study group.Another 48 patients with atypical endome⁃trial hyperplasia were selected as the control group.The expressions of ER,PR,Ki-67 and C-erbB-2 in the lesions of the two groups of patients were detected.The positive expression rates of ER,PR,Ki-67 and C-erbB-2 in EC le⁃sions were compared between the two groups of patients and in different clinicopathological study groups.Results The positive expression rates of ER and PR in the study group were 53.85%and 50.00%lower than those in the control group(83.33%,83.33%),the difference was statistically significant(χ^(2)=9.974,12.359,P<0.05).The positive ex⁃pression rates of Ki-67 and C-erbB-2 were(76.92%,75.00%)higher than the control group(20.83%,25.00%),the difference was statistically significant(χ^(2)=31.410,24.970,P<0.05).The pathological stage of EC patients in the study group was stage 3 to 4,the degree of muscle invasion≥1/2,the positive expression rate of ER was 22.73%,29.63%,43.27%and 25.00%,and the positive expression rate of PR was 22.73%,25.93%,37.84%,25.00%were lower than stage 1-2,the degree of muscle invasion was less than 1/2,well-differentiated and no lymph node metastasis were(76.67%,80.00%,80.00%,71.88%;70.00%,76.00%,80.00%,65.63%),the difference was statistically significant(χ^(2)=14.859,13.252,5.802,10.882,11.346,13.019,7.589,8.125,P<0.05).The pathological stage of EC patients in the study group was stage 3-4,the degree of muscle invasion was≥1/2,the positive expression rate of Ki-67(95.45%,96.30%,94.59%,95.00%)and The positive expression rates of C-erbB-2(95.45%,100.00%,89.19%,95.00%)were higher than those of stage 1-2 the degree of muscle invasion was

关 键 词：子宫内膜癌 雌孕激素受体 KI-67 C-ERBB-2 病理 

分 类 号：R737[医药卫生—肿瘤]