Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders  

作　　者：Yun Fan Qinyue Zhao Wencheng Xia Youqi Tao Wenbo Yu Mingjia Chen Yiqi Liu Jue Zhao Yan Shen Yunpeng Sun Chenfang Si Shenqing Zhang Yaoyang Zhang Wensheng Li Cong Liu Jian Wang Dan Li 

机构地区：[1]Department of Neurology and National Research Center for Aging and Medicine&National Center for Neurological Disorders,State Key Laboratory of Medical Neurobiology,Huashan Hospital,Fudan University,Shanghai,China [2]Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education),Shanghai Jiao Tong University,Shanghai,China [3]BioX-Renji Hospital Research Center,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China [4]Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China [5]University of Chinese Academy of Sciences,Beijing,China [6]Department of Anatomy and Histoembryology,School of Basic Medical Sciences,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institutes of Brain Science,Fudan University,Shanghai,China [7]Zhangjiang Institute for Advanced Study,Shanghai Jiao Tong University,Shanghai,China

出　　处：《Cell Research》2022年第6期585-588,共4页细胞研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(82188101,32171236,31872716,82171421,91949118,81771372 and U1932204);the Major State Basic Research Development Program of China(2019YFE0120600);the National Health Commission of China(Pro20211231084249000238);the Science and Technology Commission of Shanghai Municipality(20XD1425000,2019SHZDZX02 and 21S31902200);the Shanghai Municipal Science and Technology Major Project(2018SHZDZX01);Zhangjiang Lab,and Shanghai Center for Brain Science and Brain-Inspired Technology,the CAS project for Young Scientists in Basic research(YSBR-009);the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-005);the Science Innovation 2030-Brain Science and Brain-Inspired Intelligence Technology Major Project(2021ZD0201104)from the Ministry of Science and Technology of China.

摘　　要：Dear Editor,Protein amyloid aggregation is a histological hallmark of neurodegenerative diseases(NDs).1,2 In synucleinopathies including Parkinson’s disease(PD),Parkinson’s disease dementia(PDD),dementia with Lewy body and multiple system atrophy,αsynuclein(α-syn)is commonly characterized to form amyloid aggregates presenting distinct pathological activities in diseased brains.3,4 Structural characterization ofα-syn amyloid fibrils formed in different diseases could provide mechanistic understanding of heterogeneousα-syn pathologies.

关 键 词：AMYLOID diseases FIBRILLATION 

分 类 号：R742.5[医药卫生—神经病学与精神病学]