Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo  

作　　者：Mengjiao Li Zi-Wei Ye Kaiming Tang Liang Guo Wenwen Bi Yuyuan Zhang Yan-dong Tang Guoguang Rong Mohamad Sawan Xin Yin Ren Sun Shuofeng Yuan Bobo Dang 

机构地区：[1]Fudan University,Shanghai,China [2]Key Laboratory of Structural Biology of Zhejiang Province,School of Life Sciences,Westlake University,Hangzhou,Zhejiang,China [3]Center for Infectious Disease Research,Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou,Zhejiang,China [4]Institute of Biology,Westlake Institute for Advanced Study,Hangzhou,Zhejiang,China [5]Department of Microbiology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China [6]State Key Laboratory of Emerging Infectious Diseases,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China [7]State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin,China [8]CenBRAIN Lab.,School of Engineering,Westlake University,Hangzhou,Zhejiang,China [9]CenBRAIN Lab.,Westlake Institute for Advanced Study,Hangzhou,Zhejiang,China [10]School of Biomedical Sciences,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam,Hong Kong,China

出　　处：《Cell Research》2022年第6期589-592,共4页细胞研究（英文版）

基　　金：supported by the Westlake Education Foundation and Tencent Foundation,the Key R&D Program of Zhejiang Province(2021C03040);the National Natural Science Foundation of China(22077104,32120103013);supported by funding to The University of Hong Kong:the Health and Medical Research Fund(COVID1903010-Project 15 and 20190732,20190692);the Food and Health Bureau,the Government of the Hong Kong Special Administrative Region;the Theme-Based Research Scheme of the Research Grants Council(T11-709/21-N).

摘　　要：Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has resulted in a severe global pandemic that has lasted for more than two years.1 Several vaccines were developed at an unprecedented speed to protect billions of people.2 Many monoclonal antibodies have also been discovered,several of which are in the clinical stages.3 However,limited vaccine availability and vaccine hesitancy compromise the impact of vaccines.The continuous evolution of SARS-CoV-2 has also resulted in many variants that can escape immunity,reducing the effects of vaccines and antibodies.4 With more than 30 mutations in the spike protein,the Omicron variant escapes the majority of existing antibodies and extensively evades vaccine-induced immunity.5,6 Thus,therapeutics that are broadly effective against current and future emerging SARS-CoV-2 variants are still highly desirable.

关 键 词：ACE2 VACCINE immunity 

分 类 号：R563.1[医药卫生—呼吸系统]