单纯疱疹病毒性基质坏死型角膜炎的治疗  

The treatment of herpes simplex virus necrotizing stromal keratitis

作　　者：倪妍 郑利斌 许叶圣[1] 姚玉峰[1] Ni Yan;Zheng Libin;Xu Yesheng;Yao Yufeng(Department of Ophthalmology,Sir RunRun Shaw Hospital,Zhejiang University School of Medicine,Key Laboratory for Corneal Diseases Research of Zhejiang Province,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院眼科浙江省角膜病研究重点实验室,杭州310000

出　　处：《国际眼科纵览》2022年第3期247-252,共6页International Review of Ophthalmology

基　　金：浙江省重点研发项目(2018C03082);国家自然科学基金(U20A20387);浙江省医药卫生科技计划项目(WKJ-ZJ-1905);浙江省医药卫生科技计划项目(2019ZD040)。

摘　　要：单纯疱疹病毒性基质坏死型角膜炎(herpes simplex virus necrotizing stromal keratitis,HSV NSK)是一种较为少见的、主要表现为角膜基质坏死的眼病,其可导致视力下降、角膜穿孔,甚至失明、眼球摘除等严重后果。目前针对HSV NSK的治疗方法分为非手术治疗和手术治疗。非手术治疗包括核苷类似物等抗病毒药物、靶向γ-干扰素的反义寡核苷酸药物、富马酸二甲酯、环孢素A、疫苗等。对于非手术疗法无法控制的严重病例,需进行手术治疗,常见的术式为穿透性角膜移植、深板层角膜移植、多层羊膜移植、结膜瓣覆盖等。Herpes simplex virus necrotizing stromal keratitis(HSV NSK)is a kind of rare eye disease mainly characterized by stromal necrosis,which can lead to vision loss,corneal perforation,even blindness and enucleation.At present,the management of HSV NSK can be divided into non-surgical procedure and surgical treatment.Non-surgical procedure includes antiviral drugs such as nucleoside analogues,IFN-γ-ASON,DMF,CsA,vaccine,etc.In the event of serious cases beyond the control of non-surgical therapy,surgical management is necessary.Common clinical surgeries include penetrating keratoplasty(PKP),deep anterior lamellar keratoplasty(DALK),multilayer amniotic membrane transplantation(AMT),and conjunctival flap coverage and so on.

关 键 词：单纯疱疹病毒 基质坏死型角膜炎 炎性反应 角膜移植 

分 类 号：R772.21[医药卫生—眼科]