小胶质细胞在阿尔茨海默病神经炎性反应中作用的研究进展  

Function of the microglia in neuroinflammation of Alzheimer’s disease:a brief review

作　　者：王远卓 郑清月 张翰林 仇文颖[1] 王涛[1] 马超[1] WANG Yuan-zhuo;ZHENG Qing-yue;ZHANG Han-lin;QIU Wen-ying;WANG Tao;MA Chao(Department of Anatomy,Histology and Embryology,Institute of Basic Medical Sciences CAMS,School of Basic Medicine PUMC,Beijing 100005;Department of Clinical Medicine,Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础学院人体解剖学与组织学胚胎学系,北京100005 [2]北京协和医学院临床医学系,北京100730

出　　处：《基础医学与临床》2022年第8期1310-1313,共4页Basic and Clinical Medicine

摘　　要：阿尔茨海默病(AD)患者脑区存在不同分型的激活小胶质细胞。随神经炎性反应进展,这些细胞存在明显形态学和功能变化。它们通过改变细胞吞噬功能、参与免疫反应、或诱导胞内毒性反应来发挥致病作用。针对小胶质细胞在AD神经炎性反应中的作用,目前已开展一系列临床药物实验来推进靶向治疗。亟需更多研究来阐明小胶质细胞在AD神经炎性反应中的作用和机制。Different types of activated imbroglio exist in the brain of the patients with Alzheimer’s disease(AD). As the neuroinflammation reaction progresses, significant changes take place in the morphology and function of those cells. They could play a pathogenic role by altering the phagocytic function of cells, including intracellular toxic reactions or directly participate in immune response. Several clinical trials have been conducted to promote targeted therapy focusing on the role that microglia played in neuroinflammation reactions of AD. More large scale studies are necessary to elucidate the function and mechanism of microglia in the neuroinflammation reaction of AD.

关 键 词：阿尔茨海默病 小胶质细胞 神经炎性反应 

分 类 号：R741.02[医药卫生—神经病学与精神病学]