卡马西平与地西泮联合治疗对脑梗死并发不同癫痫发作类型的临床效果  

Clinical Effect of Carbamazepine Combined with Diazepam on Cerebral Infarction Complicated with Different Types of Epileptic Seizures

作　　者：朱琴[1] ZHU Qin(Taizhou Third People’s Hospital,Taizhou 225300,China)

机构地区：[1]泰州市第三人民医院,江苏泰州225300

出　　处：《中外医学研究》2022年第20期124-127,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究卡马西平与地西泮联合治疗对脑梗死并发不同癫痫发作类型的临床效果。方法:选取2019年5月-2021年5月泰州市第三人民医院接受治疗的脑梗死并发癫痫60例患者,根据癫痫不同发作类型分组,迟发型癫痫组20例,早发型癫痫组40例,两组均予卡马西平与地西泮联合治疗,对比癫痫发作、神经功能及日常生活能力与生活质量评分情况。结果:比较两组治疗后4、6、8、10周的癫痫发作情况,早发型癫痫组发作次数少于迟发型癫痫组(P<0.05)。比较治疗后3个月两组NDS评分、NIHSS评分可见,早发型癫痫组低于迟发型癫痫组,且前者ADL评分高于后者(P<0.05)。对比治疗后3个月两组生活质量评分,早发型癫痫组较迟发型癫痫组显著高(P<0.05)。结论:卡马西平与地西泮联合治疗对脑梗死并发早发型癫痫患者效果较好,可缓解癫痫发作,改善神经功能,提高生活能力及生活质量,但对迟发型癫痫患者效果一般。Objective:To explore the clinical effect of Carbamazepine combined with Diazepam on cerebral infarction complicated with different types of epileptic seizures.Method:A total of 60 patients with cerebral infarction complicated with epilepsy who treated in Taizhou Third People’s Hospital from May 2019 to May 2021 were selected and divided into late-onset epilepsy group(n=20)and early-onset epilepsy groups(n=40)according to different types of epileptic seizures.Both groups were treated with Carbamazepine and Diazepam.The epileptic seizures,neurological function,ability of daily living and quality of life scores were compared.Result:The epileptic seizures at 4,6,8 and 10 weeks after treatment,the number of seizures in the early-onset epilepsy group were fewer than those in the late-onset epilepsy group(P<0.05).The NDS and NIHSS scores at 3 months after treatment in the early-onset epilepsy group were lower than those in the late-onset epilepsy group,and the ADL scores in the early-onset epilepsy group was higher than that in the late-onset epilepsy group(P<0.05).The quality of life scores in the early-onset epilepsy groups at 3 months after treatment were significantly higher than those in the late-onset epilepsy group(P<0.05).Conclusion:The combined treatment of Carbamazepine and Diazepam has a better therapeutic effect on patients with cerebral infarction complicated with early-onset epilepsy,which can relieve epileptic seizures,improve neurological function,and improve living ability and quality of life,but the effect is not good for patients with late-onset epilepsy.

关 键 词：卡马西平 癫痫 脑梗死 地西泮 癫痫症状 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R743.33[医药卫生—临床医学]