加味仙方活命饮对腹腔镜宫颈癌根治术术后疗效分析  

Analysis of postoperative therapeutic efficacy of modified Xianfang Huoming Decoction on laparoscopic radical resection of cervical cancer

作　　者：高琦 刘立慧 田晓娜[2] 吴琴玲 侯玉华 GAO Qi;LIU Lihui;TIAN Xiaona;WU Qinling;HOU Yuhua(Department of Gynecology,Shenzhen Pingle Orthopaedic Hospital(Pingshan District Hospital of Traditional Chinese Medicine),Guangdong,Shenzhen 518038,China;Department of Gynecology,Zhengzhou Central Hospital,Henan,Zhengzhou 450001,China)

机构地区：[1]深圳平乐骨伤科医院(坪山区中医院)妇科,广东深圳518038 [2]郑州市中心医院妇科,河南郑州450001

出　　处：《中国医药科学》2022年第14期73-76,101,共5页China Medicine And Pharmacy

基　　金：广东省深圳市坪山区卫生系统科研项目(201913)。

摘　　要：目的探讨加味仙方活命饮对湿热瘀毒型宫颈癌在腹腔镜术后预防血栓和感染的临床疗效。方法选取2019年11月至2021年8月在深圳平乐骨伤科医院(坪山区中医院)和郑州市中心医院妇科分期为Ⅰa1~Ⅱb2期宫颈癌患者80例,均符合中医湿热瘀毒型,按照随机数表法分为治疗组和对照组,每组各40例。对照组行腹腔镜下广泛全子宫切联合淋巴结清扫术即宫颈癌根治术,术后尿管插管、抗生素预防感染,治疗组在对照组基础上服用加味仙方活命饮5 d。观察两组术前和术后5 d纤维蛋白原(FIB)、D-二聚体(D-D)、血小板数量(PLT)、降钙素原(PCT)、C反应蛋白(CRP)、湿热瘀毒中医症候评分以及术后感染状况。结果术后,治疗组D-D、FIB、PLT、PCT、CRP、湿热瘀毒中医症候积分低于对照组,差异有统计学意义(P<0.05)。结论加味仙方活命饮通过扶正祛邪改善腹腔镜下宫颈癌根治术术后湿热瘀毒中医型症候,改善术后高凝血状态,减少血栓发生的风险,预防宫颈癌术后早期感染。Objective To investigate the clinical efficacy of modified Xianfang Huoming Decoction in preventing thrombosis and infection of cervical cancer with damp-heat and blood stasis toxin after laparoscopic surgery.Methods A total of 80 patients with cervical cancer ofⅠa1~Ⅱb2,who conformed to damp heat and blood stasis toxin type and were admitted to the Department of Gynecology of Shenzhen Pingle Orthopaedic Hospital(Pingshan District Hospital of Traditional Chinese Medicine)and Zhengzhou Central Hospital from November 2019 to August 2021 were selected.They were divided i nto the treatment group(n=40)and the control group(n=40)according to the random number table method.The control group was treated with laparoscopic extensive hysterectomy combined with lymph node dissection,that is,radical hysterectomy for cervical cancer,postoperative urinary catheterization and antibiotics to prevent infection.While the treatment group was treated with modified Xianfang Huoming Decoction for 5 days on the basis of the control group.Fibrinogen(FIB),D-dimer(D-D),platelet count(PLT),procalcitonin(PCT),C-reactive protein(CRP),TCM syndrome score of damp-heat and blood stasis toxin and postoperative infection condition were observed before operation and on the 5th day after the operation.Results After the operation,the scores of D-D,FIB,PLT,PCT,CRP,TCM syndrome score of damp-heat and blood stasis toxin in the treatment group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion Modified Xianfang Huoming Decoction can improve the TCM syndrome of damp-heat and blood stasis toxin after laparoscopic radical hysterectomy for cervical cancer by strengthening the body resistance and eliminating pathogenic factors,improve the postoperative hypercoagulable state,reduce the risk of thrombosis,and prevent early postoperative infection of cervical cancer.

关 键 词：宫颈癌 湿热瘀毒 加味仙方活命饮 凝血 感染 

分 类 号：R737.33[医药卫生—肿瘤]