炎症性肠病住院患者的疲劳现况研究与生活质量分析  

Prevalence study on fatigue and analysis about quality of life in inpatients with inflammatory bowel disease

作　　者：李宝悦 王丹丹[1] 郝娜[1] 王素敏[1] 张哲 冯百岁[1] LI Baoyue;WANG Dandan;HAO Na;WANG Sumin;ZHANG Zhe;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Henan,Zhengzhou 450014,China)

机构地区：[1]郑州大学第二附属医院消化内科,河南郑州450014

出　　处：《中国医药科学》2022年第13期6-9,56,共5页China Medicine And Pharmacy

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20200399,LHGJ20190327,LHGJ20190311);郑州大学学科建设重点专项前沿交叉专项项目(XKZDQY201906)。

摘　　要：目的通过问卷调查的方法研究炎症性肠病(IBD)住院患者的疲劳现况及其影响因素,进一步分析疲劳对生活质量(QoL)的影响,为IBD患者的临床管理优化提供依据。方法采用纸质问卷的方式对郑州大学第二附属医院2021年4月20日至7月20日的住院IBD患者进行问卷调查,最终获得121份有效问卷,包括溃疡性结肠炎(UC)45份、克罗恩病(CD)76份。收集相关临床信息和血清学指标进行分析。结果单因素分析中,两组复发次数、病情、睡眠时间、贫血、肠外病变和并发症、近6个月手术史、营养不良风险、低蛋白血症、焦虑阳性、抑郁阳性差异有统计学意义(P<0.05)。将其纳入logistic回归分析,仅营养不良风险、焦虑阳性是疲劳发生的独立影响因素(P<0.05)。疲劳组患者QoL显著下降,多元线性回归分析提示整体疲劳、躯体疲劳、动机减少可显著降低IBD住院患者的QoL(P<0.05)。结论营养不良风险、焦虑是疲劳发生的独立影响因素,疲劳严重影响了IBD患者的QoL。及时有效地进行心理健康咨询评估、纠正营养风险等对IBD患者疲劳缓解和提升QoL有所裨益。Objective The status and influencing factors of fatigue of inpatients with inflammatory bowel disease(IBD) were studied by questionnaire survey. Then the effect of fatigue on quality of life(QoL) was analyzed. To provide basis for the optimization of the clinical management of IBD patients. Methods A total of 121 IBD patients(45 patients with ulcerative colitis [UC] and 76 patients with Crohn’s disease [CD]) who hospitalized in the Second Affiliated Hospital of Zhengzhou University from April 20 to July 20, 2021 were studied by paper questionnaire. Their relevant clinical information and serological indicators for analysis. Results Relapses times, illness, sleep duration,anemia, extraintestinal lesions and complications, surgery in recent 6 months, risk of malnutrition, hypoproteinemia,anxiety and depression in two groups were statistically different in the monofactor analysis of fatigue(P < 0.05). By logistic regression, only the risk of malnutrition and positive anxiety were the independent influencing factors for the occurrence of fatigue(P < 0.05). The QoL decreased significantly in fatigue group. General fatigue, physical fatigue and reduced motivation significantly decreased QoL of IBD inpatients by multiple linear regression analysis(P < 0.05). Conclusion The risk of malnutrition and anxiety are independent influencing factors for the occurrence of fatigue. And fatigue clearly affects the QoL of inpatients with IBD. Timely and effective mental health counseling and evaluation, and measures such as correcting malnutrition was beneficial to the relief of fatigue and improvement of QoL.

关 键 词：炎症性肠病 疲劳 生活质量 问卷调查 

分 类 号：R574[医药卫生—消化系统]