性激素结合蛋白、补体因子H在精神分裂症合并抑郁患者血清中的表达及与患者社会功能的关系分析  

The Expression of Sex Hormone Binding Globulin and Complement Factor H in the Serum of Patients with Schizophrenia Complicated with Depression and Their Relationship with the Social Function of the Patients

作　　者：王天明 江小建 黄德强 WANG Tianming;JIANG Xiaojian;HUANG Deqiang(Ruijin Ankang Hospital,Jiangxi Province,Ruijin 342500,China;不详)

机构地区：[1]江西省瑞金安康医院,江西瑞金342500 [2]江西省赣州市第三人民医院

出　　处：《中国医学创新》2022年第21期134-138,共5页Medical Innovation of China

基　　金：江西省卫生和计划生育委员会项目(20187276)。

摘　　要：目的:探讨性激素结合蛋白(SHBG)、补体因子H(CFH)在精神分裂症合并抑郁患者血清中的表达及与患者社会功能的关系。方法:选取2020年1月-2021年3月瑞金安康医院收治的88例精神分裂症患者纳入研究,根据患者是否合并抑郁,将其分为伴抑郁的精神分裂症组(n=40)和不伴抑郁的精神分裂症组(n=48),另选取体检健康者35例作为对照组。检测并比较各组血清SHBG及CFH水平。采用阳性与阴性症状量表(PANSS)评价患者精神状态,采用卡尔加里精神分裂症抑郁量表(CDSS)评价患者抑郁水平,采用个体与社会功能量表(PSP)评价患者社会功能,SHBG、CFH表达与各量表评分的关系采用Pearson相关性分析。应用ROC曲线分析血清SHBG及CFH诊断精神分裂症合并抑郁的临床价值。结果:与对照组比较,伴抑郁的精神分裂症组及不伴抑郁的精神分裂症组血清SHBG水平均较高,而血清CFH水平均较低(P<0.05);与不伴抑郁的精神分裂症组比较,伴抑郁的精神分裂症组血清SHBG水平较高,而血清CFH水平较低(P<0.05)。与不伴抑郁的精神分裂症组比较,伴抑郁的精神分裂症组PANSS评分及CDSS评分较高,而PSP评分较低(P<0.05)。伴抑郁的精神分裂症组患者血清SHBG水平与PANSS评分、CDSS评分均呈正相关,与PSP评分呈负相关(P<0.05);伴抑郁的精神分裂症组患者血清CFH水平与PSP评分呈正相关,与PANSS评分、CDSS评分均呈负相关(P<0.05)。血清SHBG、CFH诊断精神分裂症合并抑郁的敏感度分别为94.87%、92.11%,特异度分别为87.23%、79.25%。结论:精神分裂症合并抑郁患者血清中SHBG的表达增加,而CFH的表达下降,其表达水平与患者病情及社会功能密切相关,血清SHBG及CFH可用于临床精神分裂症合并抑郁的辅助诊断及病情严重程度的评估。Objective:To explore the expression of sex hormone binding globulin(SHBG)and complement factor H(CFH)in the serum of patients with schizophrenia complicated with depression and their relationship with the social function of the patients.Method:A total of 88 patients with schizophrenia admitted to Ruijin Ankang Hospital from January 2020 to March 2021 were selected for the study.According to whether the patients were complicated with depression,they were divided into the schizophrenic group with depression(n=40)and the schizophrenic group without depression(n=48).35 healthy people were selected as the control group.The levels of serum SHBG and CFH in each group were detected and compared.The positive and negative symptom scale(PANSS)was used to evaluate the patients’mental status,the Calgary depression scale for schizophrenia(CDSS)was used to evaluate the patients’depression level,and the personal and social performance scale(PSP)was used to evaluate the patients’social function.The relationship between the expression of SHBG and CFH and the scores of each scale was analyzed by Pearson correlation.ROC curve was used to analyze the clinical value of serum SHBG and CFH in the diagnosis of schizophrenia complicated with depression.Result:Compared with the control group,the levels of serum SHBG were higher in the schizophrenia group with depression and the schizophrenia group without depression,but the levels of serum CFH were lower(P<0.05);compared with the schizophrenia group without depression,the level of serum SHBG was higher and the level of serum CFH was lower in the schizophrenia group with depression(P<0.05).Compared with the schizophrenia group without depression,PANSS and CDSS scores in the schizophrenia group with depression were higher,PSP score in the schizophrenia group with depression was lower(P<0.05).The level of SHBG in schizophrenic patients with depression was positively correlated with PANSS and CDSS scores,and negatively correlated with PSP scores(P<0.05);the level of serum CFH in schizoph

关 键 词：性激素结合蛋白 补体因子H 精神分裂症 抑郁 社会功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]