结直肠癌外周血循环肿瘤细胞研究进展  

Research Progress of Circulating Tumor Cells in Peripheral Blood with Colorectal Cancer

作　　者：罗善山[1] LUO Shanshan(Guangxi Medical University Cancer Hospital,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院(广西结直肠癌临床研究中心),广西南宁530021

出　　处：《中国医学创新》2022年第21期167-170,共4页Medical Innovation of China

基　　金：广西壮族自治区卫生厅自筹经费科研课题(Z2014253)。

摘　　要：我国结直肠癌发病率高,死亡率高,其中晚期结直肠癌占比较大。肿瘤转移是一个涉及多步骤、多因素的复杂过程,在最初阶段,肿瘤细胞的脱落、迁移、侵袭并进入血液循环,为最终形成可被影像学检测的肿瘤转移病灶提供了条件。外周血循环肿瘤细胞(circulating tumor cells,CTCs)伴随着肿瘤发展过程并携带了其分子生物信息。因此,外周血中CTCs检测及其与肿瘤的相关性,逐渐成为临床研究的热点。本文就结直肠癌中CTCs的检测、临床意义方面进行综述。The incidence rate and mortality of colorectal cancer are high in China,and advanced tumors account for a large proportion.Tumor metastasis is a complex process involving multiple steps and factors,in the initial stage,tumor cells fall off,migrate,invade and enter into the blood circulation,which provides conditions for the final formation of tumor metastasis lesions that can be detected by imaging.Circulating tumor cells(CTCs)in peripheral blood accompany the process of tumor development and carry their molecular biological information.Therefore,the detection of circulating CTCs in peripheral blood and its correlation with tumor have gradually become the focus of clinical research.This paper reviews the detection and clinical significance of CTCs in colorectal cancer.

关 键 词：循环肿瘤细胞 结直肠癌 肿瘤转移 

分 类 号：R735.34[医药卫生—肿瘤]