Role of micronutrients in Alzheimer's disease:Review of available evidence  

作　　者：Hong-Xin Fei Chao-Fan Qian Xiang-Mei Wu Yu-Hua Wei Jin-Yu Huang Li-Hua Wei 

机构地区：[1]Department of Pathology,Guangxi University of Science and Technology,Liuzhou 545000,Guangxi Zhuang Autonomous Region,China [2]Department of Neurology,The First Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou 545000,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2022年第22期7631-7641,共11页世界临床病例杂志

基　　金：Supported by Guangxi Zhuang Autonomous Region Natural Science Fund,No. 2020GXNSFAA297001;Guangxi Zhuang Autonomous Region Liuzhou Science and Technology Program Fund,No. 2020NBAA0805;Guangxi University of Technology;No. 20Z06;Jiangxi Social Science Research and Planning Fund,No. 19JY34

摘　　要：Alzheimer's disease(AD)is one of the most common age-related neurodegenerative disorders that have been studied for more than 100 years.Although an increased level of amyloid precursor protein is considered a key contributor to the development of AD,the exact pathogenic mechanism remains known.Multiple factors are related to AD,such as genetic factors,aging,lifestyle,and nutrients.Both epidemiological and clinical evidence has shown that the levels of micronutrients,such as copper,zinc,and iron,are closely related to the development of AD.In this review,we summarize the roles of eight micronutrients,including copper,zinc,iron,selenium,silicon,manganese,arsenic,and vitamin D in AD based on recently published studies.

关 键 词：Alzheimer’s disease IRON MICRONUTRIENT ZINC 

分 类 号：R749.16[医药卫生—神经病学与精神病学]