Non-secretory multiple myeloma expressed as multiple extramedullary plasmacytoma with an endobronchial lesion mimicking metastatic cancer:A case report  

作　　者：Seul Bi Lee Chi Young Park Hee Jeong Lee Ran Hong Woo Shin Kim Sang-Gon Park 

机构地区：[1]Department of Hemato-oncology,Chosun University Hospital,Gwangju 501-717,South Korea [2]Department of Pathology,Chosun University Hospital,Gwangju 501-717,South Korea [3]Department of Laboratory Medicine,Chosun University Hospital,Gwangju 501-717,South Korea

出　　处：《World Journal of Clinical Cases》2022年第22期7899-7905,共7页世界临床病例杂志

基　　金：Supported by the Clinical Medicine Research Institute at Chosun University Hospital (2019)

摘　　要：BACKGROUND Non-secretory multiple myeloma(MM)is a rare condition that accounts for only 3%of MM cases and is defined by normal serum and urine immunofixation and a normal serum free light chain ratio.Non-secretory MM with multiple extramedullary plasmacytomas derived from endobronchial lesions is extremely rare and can be misdiagnosed as metastasis of solid cancer.CASE SUMMARY A 36-year-old man presented with progressive facial swelling and nasal congestion with cough.Various imaging studies revealed an endobronchial mass in the left bronchus and a large left maxillary mass with multiple destructive bone metastatic lesions.He initially presented with lung cancer and multiple metastases.However,pathologic reports showed multiple extramedullary plasmacytomas in the left maxilla and the left bronchus.There was no change in the serum and urine monoclonal protein levels,and no abnormalities were observed in laboratory examinations,including hemoglobin,calcium,and creatinine levels.The bone marrow was hypercellular,with 13.49%plasma cells.The patient was diagnosed with non-secretory MM expressed as multiple extramedullary plasmacytomas with endobronchial lesions in a rare location.Radiation therapy for symptomatic lesions with high-dose dexamethasone was started,and the size of the left maxillary sinus lesion dramatically decreased.In the future,chemotherapy will be administered to control lesions in other areas.CONCLUSION We present a rare case of non-secretory MM with multiple extramedullary plasmacytoma with an endobronchial lesion.

关 键 词：Maxillary mass lesion Destructive bone metastatic lesion Multiple extramedullary plasmacytoma Endobronchial lesion Non-secretory multiple myeloma Case report 

分 类 号：R733.3[医药卫生—肿瘤]