Genetics of adult attachment and the endogenous opioid system  

作　　者：Alfonso Troisi 

机构地区：[1]Department of Systems Medicine,University of Rome Tor Vergata,Rome 00133,Italy

出　　处：《World Journal of Psychiatry》2022年第8期1105-1107,共3页世界精神病学杂志

摘　　要：Since the pioneering work by Panksepp et al,the neurobiological bases of attachment behavior have been closely linked with opioid neurotransmission.Candidate gene studies of adult individuals have shown that variation in the muopioid receptor gene(OPRM1)influences attachment behavior.Early maternal care and the A/A genotype of the A118G polymorphism interact in modulating levels of fearful attachment.Compared to their counterparts carrying the A/A genotype,individuals expressing the minor 118G allele show lower levels of avoidant attachment and experience more pleasure in social situations.Brain imaging research has strengthened the biological plausibility of candidate gene studies.The avoidance dimension of attachment correlates negatively with muopioid receptor availability in the thalamus and anterior cingulate cortex,as well as the frontal cortex,amygdala,and insula.Overall,findings from human studies combined with those from animal models suggest that research on the genetic bases of attachment should include the endogenous opioid system among the investigated variables.

关 键 词：GENETICS Avoidant attachment Fearful attachment Endogenous opioids OPRM1 A118G polymorphism 

分 类 号：R749[医药卫生—神经病学与精神病学]