Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer  

作　　者：Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza 

机构地区：[1]Department of Medical Oncology,Hospital Professor Doutor Fernando Fonseca EPE,Amadora 2720-276,Portugal [2]Department of Medical Oncology,Centro Hospitalar Barreiro-Montijo EPE,Barreiro 2830-003,Portugal [3]Department of Medical Oncology,Hospital do Espírito Santo deÉvora EPE,Évora 7000-811,Portugal [4]Department of Medical Oncology,Centro Hospitalar Universitário do Algarve EPE,Algarve 8000-386,Portugal [5]Department of Medical Oncology,Hospital São Francisco Xavier,Centro Hospitalar Lisboa Ocidental EPE,Lisboa 1449-005,Portugal [6]Department of Medical Oncology,Hospital Santo António dos Capuchos,Centro Hospital Lisboa Central EPE,Lisboa 1169-050,Portugal [7]Department of Medical Oncology,Hospital BeatrizÂngelo,Loures 2674-514,Portugal [8]Department of Medical Oncology,Centro Hospitalar de Trás-os-Montes e Alto Douro EPE,Vila Real 5000-508,Portugal [9]Department of Medical Oncology,Hospital da Senhora da Oliveira EPE,Guimarães 4835-044,Portugal [10]Department of Medical Oncology,Hospital Garcia de Orta EPE,Almada 2805-267,Portugal [11]Department of Medical Oncology,Hospital da Luz,Lisboa 1500-650,Portugal [12]Department of Medical Oncology,Hospital Distrital de Santarém EPE,Santarém 2005-177,Portugal

出　　处：《World Journal of Gastrointestinal Oncology》2022年第7期1307-1323,共17页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological

关 键 词：Gastric cancer Perioperative fluorouracil plus leucovorin oxaliplatin and docetaxel Neutrophil-to-lymphocyte Lymphocyte-to-monocyte Platelet-to-lymphocyte Tumor regression grade 

分 类 号：R735.2[医药卫生—肿瘤]