紧密连接蛋白Claudin-3在肝胆疾病中的研究进展  

Research progress of tight junction protein claudin-3 in hepatobiliary systemic diseases

作　　者：许祖知 费书珂 Zu-Zhi Xu;Shu-Ke Fei(Department of Hepatobiliary,Pancreatic and Splenic Surgery,The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421000,Hunan Province,China)

机构地区：[1]南华大学衡阳医学院附属第二医院肝胆胰脾外科,湖南省衡阳市421000

出　　处：《世界华人消化杂志》2022年第15期668-673,共6页World Chinese Journal of Digestology

基　　金：湖南省教育厅优秀青年项目,No.16B232;南华大学研究生科研创新项目,No.203YXC026.

摘　　要：紧密连接蛋白Claudin-3是紧密连接蛋白家族Claudins的重要成员之一,是肝胆系统中含量最多的紧密连接蛋白.在构建肝胆管细胞紧密连接、维持细胞屏障功能和分子传递功能等方面发挥重要的作用.肝脏Claudin-3的表达失调会导致肝胆系统紧密连接破坏、代谢功能、屏障功能、增殖能力和分子传递功能受损,与肝脏恶性肿瘤、胆固醇结石、慢性肝病等多种肝胆疾病的发生发展密切相关.本文就Claudin-3在肝胆疾病中的研究进展进行综述.Claudin-3 is an important member of the claudin family of tight junction proteins and is the most abundant tight junction protein in the hepatobiliary system.It plays an important role in building tight junctions of hepatobiliary cells,and maintaining cellular barrier function and molecular delivery function.Dysregulation of hepatic claudin-3 expression leads to disruption of hepatobiliary system junctions,metabolic function,barrier function,proliferation capacity,and molecular delivery function,and is closely related to the development of various hepatobiliary diseases such as hepatic malignancies,cholesterol stones,and chronic liver diseases.In this paper,we review the progress in the research of claudin-3 in hepatobiliary diseases.

关 键 词：紧密连接 CLAUDIN-3 肝胆系统疾病 

分 类 号：R575[医药卫生—消化系统]