Clinical implications and mechanism of histopathological growth pattern in colorectal cancer liver metastases  

作　　者：Bing-Tan Kong Qing-Sheng Fan Xiao-Min Wang Qing Zhang Gan-Lin Zhang 

机构地区：[1]Department of Oncology,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China [2]School of Graduates,Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《World Journal of Gastroenterology》2022年第26期3101-3115,共15页世界胃肠病学杂志（英文版）

基　　金：Supported by National Nature Science Foundation,No.81873111,No.82174454,and No.82074182;Natural Science Foundation of Beijing,No.7202066。

摘　　要：Liver is the most common site of metastases of colorectal cancer,and liver metastases present with distinct histopathological growth patterns(HGPs),including desmoplastic,pushing and replacement HGPs and two rare HGPs.HGP is a miniature of tumor-host reaction and reflects tumor biology and pathological features as well as host immune dynamics.Many studies have revealed the association of HGPs with carcinogenesis,angiogenesis,and clinical outcomes and indicates HGP functions as bond between microscopic characteristics and clinical implications.These findings make HGP a candidate marker in risk stratification and guiding treatment decision-making,and a target of imaging observation for patient screening.Of note,it is crucial to determine the underlying mechanism shaping HGP,for instance,immune infiltration and extracellular matrix remodeling in desmoplastic HGP,and aggressive characteristics and special vascularization in replacement HGP(rHGP).We highlight the importance of aggressive features,vascularization,host immune and organ structure in formation of HGP,hence propose a novel"advance under camouflage"hypothesis to explain the formation of rHGP.

关 键 词：Colorectal cancer liver metastases Histopathological growth pattern Desmoplastic histopathological growth pattern Replacement histopathological growth pattern Prognostic value Vessel co-option 

分 类 号：R735.34[医药卫生—肿瘤]