Simple approach for the histomolecular diagnosis of central nervous system gliomas based on 2021 World Health Organization Classification  

作　　者：Maher Kurdi Rana H Moshref Yousef Katib Eyad Faizo Ahmed A Najjar Basem Bahakeem Ahmed KBamaga 

机构地区：[1]Department of Pathology,Faculty of Medicine,King Abdulaziz University,Jeddah 213733,Saudi Arabia [2]Department of Neurosciences,King Faisal Specialist Hospital and Research Center,Jeddah 213733,Saudi Arabia [3]Department of Radiology,Faculty of Medicine,Taibah University,Almadinah Almunawwarah 213733,Saudi Arabia [4]Division of Neurosurgery,Department of Surgery,Faculty of Medicine,Tabuk University,Tabuk 213733,Saudi Arabia [5]College of Medicine,Taibah University,Almadinah Almunawwarah 213733,Saudi Arabia [6]Faculty of Medicine,Umm-Alqura University,Makkah 213733,Saudi Arabia [7]Department of Pediatric,Neuromuscular Medicine Unit,Faculty of Medicine and King Abdulaziz University Hospital,King Abdulaziz University,Jeddah 213733,Saudi Arabia

出　　处：《World Journal of Clinical Oncology》2022年第7期567-576,共10页世界临床肿瘤学杂志（英文版）

摘　　要：The classification of central nervous system(CNS)glioma went through a sequence of developments,between 2006 and 2021,started with only histological approach then has been aided with a major emphasis on molecular signatures in the 4^(th) and 5^(th) editions of the World Health Organization(WHO).The recent reformation in the 5th edition of the WHO classification has focused more on the molecularly defined entities with better characterized natural histories as well as new tumor types and subtypes in the adult and pediatric populations.These new subclassified entities have been incorporated in the 5^(th) edition after the continuous exploration of new genomic,epigenomic and transcriptomic discovery.Indeed,the current guidelines of 2021 WHO classification of CNS tumors and European Association of Neuro-Oncology(EANO)exploited the molecular signatures in the diagnostic approach of CNS gliomas.Our current review presents a practical diagnostic approach for diffuse CNS gliomas and circumscribed astrocytomas using histomolecular criteria adopted by the recent WHO classification.We also describe the treatment strategies for these tumors based on EANO guidelines.

关 键 词：Central Nervous System glioma Classification World Health Organization 2021 European Association of Neuro-Oncology guidelines 

分 类 号：R739.4[医药卫生—肿瘤]