ABCB9 polymorphism rs61955196 is associated with schizophrenia in a Chinese Han population  

作　　者：Xin-Wei Li Ming-Yuan Zhang Zhi-Jun Li Li-Zhe Ai Meng-Di Jin Ning-Ning Jia Meng-Tong Xie Yu-QingYang Wei-Zhen Li Lin Dong Qiong Yu 

机构地区：[1]Department of Epidemiology and Biostatistics,School of Public Health,Jilin University,Changchun 130021,Jilin Province,China [2]Department of Endemic Diseases and Parasitic Diseases Prevention,Yantai Center for Disease Control and Prevention,Yantai 264003,Shandong Province,China

出　　处：《World Journal of Psychiatry》2022年第7期904-914,共11页世界精神病学杂志

基　　金：National Natural Science Foundation of China,No.81673253;Jilin Provincial Ministry of Education S&T Project,No.JJKH20190091KJ。

摘　　要：BACKGROUND Schizophrenia(SCZ)is a complex disease which can be affected by both genetic and environmental factors.Prenatal famine exposure may cause changes in DNA methylation levels of genes.Meanwhile,maternal nutrition during pregnancy is a pivotal environmental factor in the development of SCZ.DNA methylation may be an intermediate factor mediating exposure to famine during pregnancy and SCZ,and DNA methylation quantitative trait loci might serve as a promising tool for linking SCZ and prenatal famine.AIM To analyze the association between prenatal famine exposure and SCZ risk in Northeast Han Chinese through analysis of DNA methylation related loci.METHODS A total of 954 Han Chinese from Northeast China were recruited,including 443 patients with SCZ and 511 healthy controls.The participants were further divided into famine(born in 1960-1962)and non-famine(born in 1963-1965)groups to investigate the effect of prenatal famine exposure.Four single-nucleotide polymorphisms(SNPs)selected according to the relevant literature were genotyped,namely,rs11917047 in PTPRG,rs2239681 in IGF2,rs3842756 in INSIGF,and rs61955196 in ABCB9.DNA were extracted from peripheral blood samples,and the genotypes of these SNP loci were detected using the improved Multiple Ligase Detection Reaction multiple SNP typing technique.The associations of the DNA methylation related SNPs with SCZ risk and prenatal famine,and their interactions were analyzed using logistic regression analysis and generalized multifactor dimensionality reduction(GMDR)software.RESULTS Based on the sequencing data,genotype distributions and allele frequencies of the four selected SNPs were determined.All genotype frequencies of the four SNPs in the healthy control group were tested for deviation from Hardy-Weinberg equilibrium(P>0.05).Logistic regression analysis showed that rs61955196 was significantly associated with SCZ risk in the log-additive model[odds ratio(OR):1.22;95%confidence interval(CI):1.01-1.48;P=0.040].We also found that the rs61955196 allele was re

关 键 词：SCHIZOPHRENIA Prenatal famine rs61955196 DNA methylation ABCB9 polymorphism 

分 类 号：R749.3[医药卫生—神经病学与精神病学]