基于倾向性评分匹配评估乙酰氨基酚联合佐米曲普坦治疗无先兆偏头痛的效果  

Effect of Acetaminophen Complicated by Zolmitriptan in the Treatment of Migraine Without Aura Based on Propensity Score Matching Method

作　　者：李坤 LI Kun(Department of Neurology,Zhonghui Cardiovascular Hospital of(Zhengzhou City)Henan Province,Zhengzhou 450000,China)

机构地区：[1]河南(郑州)中汇心血管病医院神经内科,河南郑州450000

出　　处：《河南医学研究》2022年第15期2816-2819,共4页Henan Medical Research

摘　　要：目的探讨基于倾向性评分匹配评估乙酰氨基酚联合佐米曲普坦治疗无先兆偏头痛的效果。方法回顾性分析2019年1月至2020年6月在河南(郑州)中汇心血管病医院就诊的95例无先兆偏头痛患者临床资料。其中对照组42例,接受乙酰氨基酚治疗,观察组53例,接受乙酰氨基酚联合佐米曲普坦治疗,收集患者性别、年龄、病程、发病部位基线资料,采用近邻法进行1∶1匹配,经倾向性评分匹配后,最终纳入观察组、对照组病例,各30例。评估治疗1个月时的治疗效果,比较两组治疗前后视觉模拟评分(VAS)、发作频率、缓解持续时间,统计两组不良反应。结果观察组治疗总有效率比对照组高(P<0.05);两组治疗1个月时头痛缓解持续时间均较治疗前延长,且观察组长于对照组,两组VAS、头痛发作频率均较治疗前降低,且观察组比对照组低(P<0.05);治疗期间,两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论采用乙酰氨基酚联合佐米曲普坦治疗无先兆偏头痛患者的效果较好,安全性佳,可有效减轻患者的疼痛程度,减少头痛发作频率,延长头痛缓解持续时间。Objective To evaluate the effect of acetaminophen complicated by zolmitriptan in the treatment of migraine without aura based on propensity score matching method.Methods The clinical data of 95 patients with migraine without aura admitted to Zhonghui Cardiovascular Hospital of(Zhengzhou City)Henan Province from January 2019 to June 2020 were retrospectively analyzed.Fourty-two cases in the control group received acetaminophen for treatment,and 53 cases in the observation group received acetaminophen complicated by zolmitriptan for treatment.The baseline data of gender,age,course of disease and location of disease of patients were collected,and the nearest neighbor method was used for 1∶1 matching.After the propensity score matching,the patients in the observation group and the control group were finally included,30 cases in each group.The therapeutic effect was evaluated at 1 month of treatment.Visual analogue score(VAS),frequency of headache attack and duration of headache relief were compared between the two groups before and after treatment,and adverse reactions of the two groups were counted.Results Compared with the control group,the total effective rate in the observation group was higher(P<0.05).The headache relief duration of both groups one month after treatment was longer than that before treatment,and the observation group was longer than that in the control group.VAS and headache frequency of both groups were decreased than those before treatment,and the observation group was lower than that in the control group(P<0.05).During treatment,there was no difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Acetaminophen complicated by zolmitriptan has better effect and higher safe in treating patients with migraine without aura,which can effectively reduce the pain degree of patients,reduce the frequency of headache attack,and prolong the duration of headache relief.

关 键 词：无先兆偏头痛 乙酰氨基酚 佐米曲普坦 疼痛程度 发作频率 不良反应 

分 类 号：R747.2[医药卫生—神经病学与精神病学]