非编码RNAs调控内皮祖细胞对静脉血栓的影响  

The role of non-coding RNAs in regulating of endothelial progenitor cells in venous thrombosis

作　　者：孙莉莉 李晓强 张明[1] 朱健 黄佃[1] Sun Lili;Li Xiaoqiang;Zhang Ming;Zhu Jian;Huang Dian(Department of Vascular Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,210008 Nanjing,China)

机构地区：[1]南京大学医学院附属鼓楼医院血管外科,210008

出　　处：《中华细胞与干细胞杂志（电子版）》2022年第3期181-185,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：国家自然科学基金(82070496)。

摘　　要：静脉血栓栓塞症(VTE)包括深静脉血栓形成(DVT)和肺栓塞(PE),是世界上第三大最常见的血管疾病,严重威胁患者生命。目前,临床上对DVT的治疗效果尚不满意。研究发现,循环内皮祖细胞在DVT的溶解和再通过程中发挥重要作用,已成为再生医学研究的热点,但不利的微环境会降低其功能作用。非编码RNAs特别是长链非编码RNAs(lncRNAs)和微小RNAs(miRNAs),对改善内皮祖细胞的生物学功能具有关键作用,可作为临床上疾病的生物学标志物及治疗靶点,研究其调控内皮祖细胞功能在VTE发生和发展过程中的作用及分子机制,将为临床上防治VTE提供理论基础和实验依据,给VTE患者带来希望。本文主要综述VTE的特征、内皮祖细胞对静脉血栓的调控作用和非编码RNAs调控内皮祖细胞对静脉血栓的影响,为VTE的诊断、预防、治疗和预后提供一定的参考价值和理论基础。Venous thromboemlism(VTE),which includes deep vein thrombosis(DVT)and pulmonary embolism(PE),is the third most common vascular disease in the world and poses serious threat to patients'lives.Currently,the clinical treatment of DVT is not very effective.Studies have found that circulating endothelial progenitor cells play an important role in the resolution and recanalization of DVT,however,the unfavorable microenvironment reduced the function.Non-coding RNAs,especially long non-coding RNAs(lncRNAs)and microRNAs(miRNAs),play an important role in improving the biological functions of endothelial progenitor cells.They can use as biological markers and therapeutic targets for clinical diseases.Studies have also found that non-coding RNAs regulated the function of endothelial progenitor cells in the occurrence and development of VTE and the molecular mechanisms,which may provide new methods for the prevention and treatment of VTE in clinic,and give hope to VTE patients.Here,we mainly review the characteristics of VTE,the regulation of endothelial progenitor cells on venous thrombosis,and the effects of non-coding RNAs on endothelial progenitor cells on venous thrombosis,which provides a certain reference value and theoretical basis for the diagnosis,prevention,treatment and prognosis of VTE.

关 键 词：lncRNAs 内皮祖细胞 静脉血栓栓塞症 静脉血栓 再生医学 

分 类 号：R73[医药卫生—肿瘤]