3-epi-bufotalin suppresses the proliferation in colorectal cancer cells through the inhibition of the JAK1/STAT3 signaling pathway  

作　　者：SANHUA LI QINGHONG KONG XIAOKE ZHANG XINTING ZHU CHUNBO YU CHANGYAN YU NIAN JIANG JING HUI LINGJIE MENG YUN LIU 

机构地区：[1]Guizhou Provincial College–Based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines,Zunyi,563000,China [2]Life Science Institute of Zunyi Medical University,Zunyi,563000,China [3]School of Preclinical Medicine of Zunyi Medical University,Zunyi,563000,China

出　　处：《BIOCELL》2022年第11期2425-2432,共8页生物细胞（英文）

基　　金：This work was supported by the Guizhou Provincial Science and Technology Program(QKHZC[2020]4Y154);Science and Technology Plan of Zunyi(ZSKHSZ[2018]18);Science and Technology Plan of Zunyi(ZSKHHZ[2020]83);the Xinmiao Funding of Zunyi Medical University(QKPTRC[2019]022);City School Joint Fund of Zunyi(ZSKHHZ[2021]277);the Innovation Talent Team of Zunyi(ZSKRC[2019]1).

摘　　要：Traditional Chinese medicine(TCM)has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers.3-epi-bufotalin is an active ingredient of TCM“Chanpi”with anti-tumor potential.However,the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed.The present study demonstrated that 3-epi-bufotalin could reduce viability,trigger apoptosis,and block the cell cycle at the G2/M stage in colorectal cancer cell lines HT29,RKO,and COLO205 in vitro.Moreover,3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway.These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells.

关 键 词：3-epi-bufotalin Colorectal cancer JAK1/STAT3 signaling pathway Apoptosis 

分 类 号：R73[医药卫生—肿瘤]