Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach  

作　　者：EJLAL ABU-EL-RUB RAMADA R.KHASAWNEH FATIMAH A.ALMAHASNEH HANA M.ZEGALLAI 

机构地区：[1]Department of Basic Medical Sciences,Faculty of Medicine,Yarmouk University,Irbid,21163,Jordan [2]Physiology and Pathophysiology,Faculty of Medicine,University of Manitoba,Winnipeg,R3E0W2,Canada [3]Department of Pharmacology&Therapeutics,University of Manitoba,Winnipeg,R3E0W2,Canada [4]DREAM,Children’s Hospital Research Institute of Manitoba,Winnipeg,R3E0W2,Canada

出　　处：《BIOCELL》2022年第4期907-911,共5页生物细胞（英文）

摘　　要：The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells(MSCs),generally referred to as the MSCs derived secretome,has substantial potential for the treatment of many chronic and degenerative diseases.MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases.Herein,we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings.

关 键 词：Mesencyhmal stem cells SECRETOME Immuno-modulation CYTOKINES Growth factors 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]