Evaluation of the hepatoprotective and antioxidant effects of Tegillarca granosa flesh body extract against potassium bromide toxicity via targeting the histomorphometry,chromosomal and expressions of TGF-β1,VEGF and COX-2 genes in rats  

作　　者：ALI H.ABU ALMAATY BASMA M.HENDAM FAYEZ ALTHOBAITI EMAN FAYAD YASMIN M.ABD EL-AZIZ 

机构地区：[1]Department of Zoology,Faculty of Science,Port Said University,Port Said,42526,Egypt [2]Department of Husbandry and Development of Animal Wealth,Faculty of Veterinary Medicine,Mansoura University,Mansoura,35516,Egypt [3]Department of Biotechnology,Faculty of Science,Taif University,Taif,21944,Saudi Arabia

出　　处：《BIOCELL》2022年第1期219-234,共16页生物细胞（英文）

基　　金：This study was funded by Taif University Researchers Supporting Project No.(TURSP-2020/222),Taif University,Taif,Saudi Arabia.

摘　　要：The hepatotoxic effect of potassium bromide(KBr)on rat liver tissues were determined,as well as the potential protective effect of Tegillaraca granosa(T.granosa)flesh body extract.Twenty adult male albino rats were equally distributed into four groups;Group(I)treated with physiological saline(control group),Group(II)was orally gavaged by 200 mg/kg of T.granosa body extract day after day,Group(III)was intoxicated by KBr(150 mg/kg bwt day after day orally)and finally,Group(IV)was given a combination of T.granosa flesh body extract plus KBr with similar doses in the second and third groups.At the end of one month,blood,liver tissue and bone marrow samples were collected to be used for the required laboratory examinations.In response to KBr toxicity,there was a significant increase in serum antioxidant biomarkers,which was accompanied by a significant change in hepatocyte ultrastructure and a significant change in carbohydrate and protein levels within the liver organ.In addition,KBr intoxication resulted in a substantial increase in the incidence of chromosomal aberrations such as holes,splits,deletions,fragments,ploidy,and ring chromosomes,as well as significant upregulation of TGF-1,VEGF,and COX-2 gene expression.The hepatotoxic effect of KBr was counteracted by treatment with T.granosa flesh body extract.T.granosa flesh body extract has a curative antioxidant and numerous protective effects against KBr hepatotoxicity.

关 键 词：Potassium bromide Tegillarca granosa Hepatic toxicity Antioxidant biomarker HISTOMORPHOMETRY Chromosomal aberrations Gene expression 

分 类 号：R73[医药卫生—肿瘤]