The role of transcriptional factor brachyury in the development and repair of nucleus pulposus  

作　　者：YINGHUI WU HONG ZHANG QIANG WANG SUOYUAN LI JUN SHEN 

机构地区：[1]Department of Orthopeadic Surgery,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Suzhou,215002,China

出　　处：《BIOCELL》2022年第6期1363-1364,共2页生物细胞（英文）

基　　金：This work was supported by the Gusu Health Talent Project of Suzhou(Grant No.GSWS2020056);“333”Talent Project of Jiangsu Province(Grant No.BRA2017057).

摘　　要：Transcription factor Brachyury,a protein containing 435 amino acids,has been widely investigated and reported in notochord differentiation and nucleus pulposus development.The crucial functions and underlying mechanisms by Brachyury are discussed in this paper,which suggests Brachyury can be developed into a potential novel target for the therapy of intervertebral disc degeneration.

关 键 词：BRACHYURY Nucleus pulposus NOTOCHORD IVD 

分 类 号：Q78[生物学—分子生物学]