Applications of scaffolds:Tools for enhancing the immunomodulation of mesenchymal stromal cells  

作　　者：OK-HYEON KIM EUN RAN KIM JUN HYUNG PARK HYUN JUNG LEE 

机构地区：[1]Department of Anatomy and Cell Biology,College of Medicine,Chung-Ang University,Seoul,06974,South Korea [2]Department of Global Innovative Drugs,Graduate School of Chung-Ang University,Seoul,06974,South Korea [3]Severance Biomedical Science Institute,Yonsei Biomedical Research Institute,College of Medicine,Yonsei University,Seoul,03722,South Korea

出　　处：《BIOCELL》2022年第6期1439-1443,共5页生物细胞（英文）

基　　金：This research is supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(Grant No.2020R1A2C2011617);by a Chung-Ang University Research Scholarship Grants in 2019.

摘　　要：Exogenously delivered mesenchymal stromal cells(MSCs)are therapeutically beneficial owing to their paracrine effect;they secrete various cytokines,nucleic acids,and proteins.Multiple bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions(both structurally and functionally).Various scaffolds mimic the natural extracellular matrix(ECM)using both natural and synthetic polymers,providing favorable environments for MSC proliferation and differentiation.Depending on material properties,either topographically or elastically structured scaffolds can be fabricated.Three-dimensional scaffolds have tunable substrate rigidities and structures,aiding MSC cultivation.Decellularized ECM-derived hydrogels are similar to the natural ECM,thus improving the paracrine effects of MSCs.Here,we discuss recent research on the application of scaffolds to maximize the immunomodulatory function of MSCs.

关 键 词：Extracellular matrix(ECM) IMMUNOMODULATION Mesenchymal stromal cells(MSCs) Scaffolds Stem cell niche 

分 类 号：R31[医药卫生—基础医学]