缺陷型精神分裂症患者的神经软体征及其与认知功能的关系  

Neurological soft signs and its relation to cognitive function in patients with deficit schizophrenia

作　　者：张红 周福春[1,2] 王传跃[1,2] ZHANG Hong;ZHOU Fuchun;WANG Chuanyue(The National Clinical Research Center for Mental Disorders and Beijing Key Laboratory of Mental Disorders and Beijing Institute for Brain Disorders Center of Schizophrenia,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China;Advanced Innovation Center for Human Brain Protection,Capital Medical University,Beijing 100069,China;Changping Hospital of Integrated Chinese and Western Medicine,1 Department of Mental Illness Combined with Somatic Disease,Beijing 102208,China)

机构地区：[1]首都医科大学附属北京安定医院,国家精神心理疾病临床医学研究中心,精神疾病诊断与治疗北京市重点实验室,北京脑重大疾病研究院精神分裂症研究所,北京100088 [2]首都医科大学人脑保护高精尖创新中心,北京100069 [3]北京市昌平区中西医结合医院,精神病合并躯体病1科,北京102208

出　　处：《中国心理卫生杂志》2022年第9期729-733,共5页Chinese Mental Health Journal

基　　金：国家自然科学基金(81971250);国家科技重大专项重大新药创制(2018ZX09201-014)。

摘　　要：目的:了解缺陷型慢性精神分裂症患者的神经软体征特征以及神经软体征与认知缺陷的关系。方法:纳入符合DSM-Ⅳ诊断标准的62例长期住院的慢性精神分裂症患者,并根据缺陷综合征诊断标准(SDS)分为缺陷型(32例)及非缺陷型(30例),使用剑桥神经系统量表(CNI)评估神经软体征(NSS),MATRICS认知成套测验(MCCB)评估认知功能,Simpson-Angus锥体外系量表(SAS)及异常非随意运动(AIMS)评估锥体外系反应。结果:缺陷型比非缺陷型精神分裂症患者具有更高的NSS总分和NSS感觉整合量表分(均P<0.05)。慢性精神分裂症患者CNI总分与MCCB总分呈负相关(r=-0.63,P<0.001)。结论:缺陷型较非缺陷型慢性精神分裂症患者存在更重的神经软体征,主要表现为感觉整合障碍,且软体征越重认知功能缺陷越明显。Objective:To explore the characteristics of neurological soft signs and the relationship between neurological soft signs and cognitive deficits in patients with chronic deficit schizophrenia.Methods:Totally 62 long-term hospitalized patients with chronic schizophrenia who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders,Fourth Edition(DSM-Ⅳ)were selected.They were divided into deficit and non-deficit schizophrenia groups according to the Schedule for the Deficit Syndrome(SDS).All the patients were assessed with the Cambridge Nervous Inventory(CNI)for neurological soft signs(NSS),Matrix Consensus Cognitive Battery(MCCB)for cognitive function,and Simpson-Angus Extra Pyramidal System Scale(SAS)and Abnormal Involuntary Movement Scale(AIMS)for extra pyramidal response.Results:The deficit patients had higher NSS total scores(P<0.05)and sensory integration scale scores(P<0.05)than non-deficit patients.There was a negative correlation between CNI total scores and MCCB total scores in patients with chronic schizophrenia(r=-0.63,P<0.001).Conclusion:It suggests that the patients with deficit schizophrenia have more neurological soft signs than those with non-deficit schizophrenia,mainly in sensory integration disorder.In patients with chronic schizophrenia,the more severe the neurological soft signs,the more significant the cognitive impairment.

关 键 词：慢性精神分裂症 缺陷综合征 神经软体征 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学] B842.1[医药卫生—临床医学]