头孢哌酮和纳米铁对青海弧菌Q67的毒性效应  

Effects of Cefoperazone and Nanoscale Zero-valent Iron on Vibrio qinghaiensis-Q67 Toxicity

作　　者：张馨月 唐雯聪 许立欣 周芮冰 于睿群 曾晴 葛艳辉[1] ZHANG Xinyue;TANG Wencong;XU Lixin;ZHOU Ruibing;YU Ruiqun;ZENG Qing;GE Yanhui(School of Environmental Science and Safety Engineering,Tianjin University of Technology,Tianjin 300384,China)

机构地区：[1]天津理工大学环境科学与安全工程学院,天津300384

出　　处：《环境科学与技术》2022年第4期8-14,共7页Environmental Science & Technology

基　　金：大学生创业创新项目(202010060096);国家自然科学基金面上项目(21276182)。

摘　　要：该研究选取头孢哌酮和零价纳米铁对青海弧菌Q67进行急性毒性实验和慢性毒性实验,结合青海弧菌Q67的发光度探讨了β-内酰胺类抗生素和纳米材料对青海弧菌Q67的毒性效应。结果表明,作用时间为15 min时,头孢哌酮、零价纳米铁单一急性毒性半数效应浓度(EC_(50))分别为178.898和175.275 mg/L;延长暴露时间到24 h,头孢哌酮、零价纳米铁慢性毒性半数效应浓度分别为59.030和152.274 mg/L。根据相加指数法判断联合毒性的作用类型,发现2种混合物对青海弧菌Q67的急性、慢性联合毒性作用类型皆为拮抗作用。In this paper,laboratory experiments were conducted regarding the acute and chronic toxicity of cefoperazone and nanoscale zero-valent iron to Vibrio qinghaiensis-Q67,and among others,toxic effects ofβ-lactam antibiotics and nanomaterials were investigated based on the luminous intensity of the bacteria.The result of the experiments suggested that the acute15 min-EC_(50)(15min 50%maximum effect concentration)of cefoperazone and nanoscale zero-valent iron were 178.898 and 175.275 mg/L,respectively;the 24 h-EC50 of cefoperazone and nanoscale zero-valent iron were respectively 59.030 and 152.274 mg/L.As for the type of combined toxicity,which was evaluated by the AI(additive index)method,it was found that the mixture of cefoperazone and nanoscale zero-valent iron was characterized with the antagonism against acute and chronic toxicity of Vibrio qinghaiensis-Q67.

关 键 词：头孢哌酮 零价纳米铁 青海弧菌Q67 毒性效应 

分 类 号：X171.5[环境科学与工程—环境科学]