Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis  

作　　者：Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang 

机构地区：[1]Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Peking University,Beijing 100191,China [2]Cardiovascular Division,BHF Center of Vascular Regeneration,King's College London,London,UK [3]Department of Clinical Laboratory,Beijing Chao-Ya ng Hospital,Capital Medical University,Beijing 100020,China [4]Department of Cardiology,The First Affiliated Hospital,Zhejiang University,Hangzhou 310003,China

出　　处：《Protein & Cell》2022年第7期540-547,共8页蛋白质与细胞（英文版）

基　　金：This work was supported by grants from National Natural Science Foundation of China(31872787,91739303,91939105,81770445,81921001,and 82170476);Natural Science Foundation of Beijing,China(No.M21008).

摘　　要：Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(>15μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking.

关 键 词：ATHEROSCLEROSIS al. metabolism 

分 类 号：R543.5[医药卫生—心血管疾病]